Modified anti-ICAM-1 antibodies and their use in the treatment o

Details Modified anti-ICAM-1 antibodies and their use in the treatment o Modified anti-ICAM-1 antibodies and their use in the treatment o

1995-04-24

1997-12-09

Feisee, Lila

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241811, 5303911, 53038885, A61K 39395, C07K 1628

Patent

active

056957602

ABSTRACT:
Methods for preventing or treating inflammation are provided. Specifically, such inflammation can be effectively treated or prevented through the use of anti-ICAM-1 antibodies which have been modified to contain poly(ethylene) glycol adducts. The modification reduces the immunoreactivity of the antibodies, and thus increases the antibodies' serum half life. Methods for forming, purifying and using such modified antibodies are described.

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