Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2006-11-07
2006-11-07
Helms, Larry R. (Department: 1643)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C530S388220, C530S330000, C530S333000, C530S329000, C424S130100, C424S133100, C424S133100, C424S143100, C435S069600, C435S173300, C435S070210, C435S071100, C435S328000, C435S069700
Reexamination Certificate
active
07132511
ABSTRACT:
The present invention relates to antibodies which are directed to the EGF receptor (HER1) to be administered especially to humans and in particular for therapeutic use in tumors. The antibodies are modified whereby the modification results in a reduced propensity for the antibody to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of anti-EGFR antibody 425 in its different forms and fragments thereof to result in Mab 425 variants that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
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patent: 5558864 (1996-09-01), Bendig et al.
patent: 5712120 (1998-01-01), Rodriguez et al.
patent: 5891996 (1999-04-01), Mateo de Acosta del Rio et al.
patent: WO 96/40210 (1996-12-01), None
patent: WO 98/52976 (1998-11-01), None
Rudikoff et al (Proc Natl Acad Sci USA 1982 vol. 79 p. 1979).
Carr Francis J.
Carter Graham
Hamilton Anita
Jones Tim
Williams Stephen
Helms Larry R.
Merck Patent GmbH
Olson & Hierl Ltd.
Tungaturthi Parithosh K.
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