Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2006-09-14
2009-12-22
Robinson, Hope A (Department: 1652)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S002600, C530S350000, C530S300000
Reexamination Certificate
active
07635678
ABSTRACT:
Modified annexin proteins, including a homodimer of human annexin V, are provided. Methods for their use, such as to prevent thrombosis without increasing hemorrhage and to attenuate ischemia-reperfusion injury (IPI), are also provided. The modified annexins bind phosphatidylserine (PS) on cell surfaces, thereby preventing the assembly of the prothromkinase complex. The modified annexin decreases the binding of leukocytes and platelets during post-ischemic reperfusion, thereby restoring microvascular blood flow and decreasing organ damage.
REFERENCES:
patent: 4002531 (1977-01-01), Royer et al.
patent: 4179337 (1979-12-01), Davis et al.
patent: 4507229 (1985-03-01), Bohn et al.
patent: 4732891 (1988-03-01), Maki et al.
patent: 4736018 (1988-04-01), Reutelingsperger et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4937324 (1990-06-01), Fujikwa et al.
patent: 4965251 (1990-10-01), Stamatoyannopoulos
patent: 5066787 (1991-11-01), Reutelingsperger et al.
patent: 5097019 (1992-03-01), Lobermann et al.
patent: 5225537 (1993-07-01), Foster et al.
patent: 5229367 (1993-07-01), Perretti et al.
patent: 5258497 (1993-11-01), Reutilingsperger et al.
patent: 5290915 (1994-03-01), Nakao et al.
patent: 5296467 (1994-03-01), Reutelingsperger et al.
patent: 5360789 (1994-11-01), Nakao et al.
patent: 5484711 (1996-01-01), Wallner et al.
patent: 5589395 (1996-12-01), Romisch et al.
patent: 5591633 (1997-01-01), Saino et al.
patent: 5608060 (1997-03-01), Axworthy et al.
patent: 5612460 (1997-03-01), Zalipsky et al.
patent: 5632986 (1997-05-01), Tait et al.
patent: 5837842 (1998-11-01), Hauptmann et al.
patent: 5849600 (1998-12-01), Nixon et al.
patent: 5955437 (1999-09-01), Reutelingsperger
patent: 5968477 (1999-10-01), Kasina et al.
patent: 6169078 (2001-01-01), Hughes et al.
patent: 6171577 (2001-01-01), Reno et al.
patent: 6194214 (2001-02-01), Kraus
patent: 6242570 (2001-06-01), Sytkowski et al.
patent: 6312694 (2001-11-01), Thorpe et al.
patent: 6323313 (2001-11-01), Tait et al.
patent: 6358508 (2002-03-01), Ni et al.
patent: 6387366 (2002-05-01), Hurwitz et al.
patent: 6962903 (2005-11-01), Allison
patent: 7407475 (2008-08-01), Allison
patent: 2002/0082623 (2002-06-01), Osther
patent: 2002/0088015 (2002-07-01), Shi
patent: 2002/0132256 (2002-09-01), Cavanaugh
patent: 2003/0027763 (2003-02-01), Bennett et al.
patent: 2003/0113330 (2003-06-01), Uhal
patent: 2003/0152513 (2003-08-01), Blankenberg et al.
patent: 2003/0175831 (2003-09-01), Canton et al.
patent: 2003/0211548 (2003-11-01), Packard et al.
patent: 2004/0002056 (2004-01-01), Lorens et al.
patent: 2004/0018590 (2004-01-01), Gernngross et al.
patent: 2004/0291151 (2004-02-01), Mahadevappa et al.
patent: 2004/0042959 (2004-03-01), Montalto et al.
patent: 2004/0171629 (2004-09-01), Zervos
patent: 2005/0053637 (2005-03-01), Ma Or
patent: 2005/0084547 (2005-04-01), Subbiah
patent: 2005/0130230 (2005-06-01), Davalos et al.
patent: 2005/0136455 (2005-06-01), Lehmann et al.
patent: 2005/0142657 (2005-06-01), Grein et al.
patent: 2005/0147692 (2005-07-01), Roth
patent: 2005/0208151 (2005-09-01), Hurez et al.
patent: 2005/0222030 (2005-10-01), Allison
patent: 2005/0244897 (2005-11-01), Zeiher et al.
patent: 1343777 (2002-04-01), None
patent: 1401662 (2003-03-01), None
patent: 1404872 (2003-03-01), None
patent: 19541284 (1995-06-01), None
patent: 0318703 (1989-07-01), None
patent: 04198195 (1992-07-01), None
patent: 5001096 (1993-01-01), None
patent: 6116286 (1994-04-01), None
patent: 7072147 (1995-03-01), None
patent: 7072149 (1995-03-01), None
patent: WO8807576 (1988-10-01), None
patent: WO 91/07187 (1991-05-01), None
patent: WO9116882 (1991-11-01), None
patent: WO9207870 (1992-05-01), None
patent: WO 92/19279 (1992-11-01), None
patent: WO9401554 (1994-01-01), None
patent: WO 95/34315 (1995-12-01), None
patent: WO9603655 (1996-02-01), None
patent: WO 97/17084 (1997-05-01), None
patent: WO 97/24440 (1997-07-01), None
patent: WO9801563 (1998-01-01), None
patent: WO 98/04294 (1998-02-01), None
patent: WO 98/31383 (1998-07-01), None
patent: WO9829442 (1998-07-01), None
patent: WO9902992 (1999-01-01), None
patent: WO 99/19470 (1999-04-01), None
patent: WO9924054 (1999-05-01), None
patent: WO9948916 (1999-09-01), None
patent: WO 0002587 (2000-01-01), None
patent: WO0010673 (2000-03-01), None
patent: WO0011026 (2000-03-01), None
patent: WO0012547 (2000-03-01), None
patent: WO0038517 (2000-07-01), None
patent: WO0111372 (2001-02-01), None
patent: WO0123426 (2001-04-01), None
patent: WO0133228 (2001-05-01), None
patent: WO0220769 (2002-03-01), None
patent: WO02067767 (2002-09-01), None
patent: WO02080754 (2002-10-01), None
patent: WO02087497 (2002-11-01), None
patent: WO 02087498 (2002-11-01), None
patent: WO02089657 (2002-11-01), None
patent: WO03103577 (2003-05-01), None
patent: WO03062264 (2003-07-01), None
patent: WO03079987 (2003-10-01), None
patent: WO03084333 (2003-10-01), None
patent: WO03093478 (2003-11-01), None
patent: WO03105814 (2003-12-01), None
patent: WO2004006963 (2004-01-01), None
patent: WO2004090554 (2004-10-01), None
patent: WO2004112717 (2004-12-01), None
patent: WO2004113561 (2004-12-01), None
patent: WO2005014801 (2005-02-01), None
patent: WO2005023096 (2005-03-01), None
patent: WO2005027965 (2005-03-01), None
patent: WO2005028490 (2005-03-01), None
patent: WO2005053744 (2005-06-01), None
patent: WO2005058351 (2005-06-01), None
patent: WO2005058352 (2005-06-01), None
patent: WO2005065418 (2005-07-01), None
patent: WO2005069000 (2005-07-01), None
patent: WO2005018436 (2005-08-01), None
patent: WO2005078124 (2005-08-01), None
patent: WO2005087275 (2005-09-01), None
patent: WO2005099744 (2005-10-01), None
patent: WO2005103720 (2005-11-01), None
Allan et al., Nature 295:612-613 (1982).
Bangham et al., J. Mol. Biol. 23:238-252 (1965).
Behr et al., Proc. Natl. Acad. Sci. USA 86:6982-6986 (1989).
Benz and Hofmann, Biol. Chem. 378:177-183 (1997).
Bernard et al., Am. Rev. Respir. Dis. 144:1095-1101 (1991).
Brittain et al., Blood 81:2137-2143 (1993).
Burger, FEBS Lett. 329:25 28 (1993).
Campos et al., Biochemistry 37:8004-8008 (1998).
Chap et al., Biochem Biophys Res Commun 1988, 150:972-978.
Chow et al., J. Lab. Clin. Med. 135:66-72 (2000).
D'Amico et al. (2000) FASEB J 14:1867-1869.
D'Amico et al. (2000) FASEB J Article 10. 1096/99-0602FJE.
Database WPI, Section CH, Weed 200036, Derwent Publications Ltd, London, Shanghai Inst Biochem Chinese Acad (2000) Abstract.
Delgado et al. (1992) Critical Rev In Therapeutic Drug Carrier Systems 9(3/4):249-304.
Felgner et al., Proc. Natl. Acad. Sci. USA 86: 7413-7417 (1987).
Fritsma, In Hemostasis and Thrombosis in the Clinical Laboratory (Corriveau, D.M. and Fritsma, G.A. Eds) J.P. Lipincott Co., Philadelphia (1989), pp. 92-124 (1991).
Fukunaga et al., Endocrinol. 115:757 (1984).
Funakoshi et al., Biochemistry (1987) 26:5572-5578.
Funakoshi et al., Biochemistry 26:8087-8092 (1987).
Gerke et al. (2002) Physiol Rev 82:331-371.
Green et al., Am. J. Hematol. 23:317 (1986).
Grundmann et al., Behring Inst Mitt 1988, 82:59-67.
Grundmann et al., Proc Natl Acad Sci USA (1988) 85:3708-3712.
Haupt et al., Crit. Care Med. 19:1339-1347 (1991).
Haut et al., J. Lab. Clin. Med. 82:44-53 (1973).
Heathcote et al., N. Engl. J. Med. 343:1673-1680 (2000).
Hebbel et al., Abstract. Clin. Res. 41:762A (1993).
Hermanson, Bioconjugate Techniques. NY, Academic Press (1996), pp. 173-176.
Huber et al., EMBO Journal 9:3867 (1990).
Iwasaki et al., J Biochem (Tokyo) 1987, 102:1261-1273.
Kang et al., Trends Cardiovasc. Med. 9:92-102 (1999).
Kaplan et al., Blood 57:199-202 (1981).
Kaplan et al., J Biol Chem (1988) 263:8037-8043.
Kassam et al. (1998) J Biol Chem 273(8):4790-4799.
Kim et al., Biochim. Biophys. Acta 728:339 (1983).
Knauf et al., J. Biol. Chem. 266:15064-15070 (1988).
Kuypers et al. (1996) Blood 87:1179-1187.
Lubin et al. (1981) J. Clin. Invest. 67:1643-1649.
Maurer-Fogy et al., Eur J Biochem (1988) 174:585-592.
Mayhew et al. (1984) Biochim. Biophys. Acta 775:169.
Meinkoth et al. (1984) Anal. Biochem. 138:267-284.
Merten et al. (1999) Circulation 99:2577-2582.
Murata et al. (1997) Nature 388:678-682.
Nakao
Alavita Pharmaceuticals, Inc.
Robinson Hope A
Swanson & Bratschun L.L.C.
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