Modified ADAMTS4 molecules and method of use thereof

Details Modified ADAMTS4 molecules and method of use thereof Modified ADAMTS4 molecules and method of use thereof

2006-10-10

2006-10-10

Nashed, Naashat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

C435S069100, C435S252300, C435S320100, C435S440000

Reexamination Certificate

active

07118902

ABSTRACT:
The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.

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