Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Modification of viruses
Patent
1997-05-09
1999-03-30
Prouty, Rebecca E.
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Modification of viruses
4351721, 435189, C12N 902, C12N 1500
Patent
active
058887903
ABSTRACT:
Disclosed is a method for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.
REFERENCES:
patent: 5443974 (1995-08-01), Hitz et al.
patent: 5614400 (1997-03-01), Cahoon et al.
patent: 5654402 (1997-08-01), Cahoon et al.
patent: 5705391 (1998-01-01), Cahoon et al.
Cahoon Edgar B.
Lindqvist Ylva
Schneider Gunter
Shanklin John
Bogosian Margaret C.
Brookhaven Science Associates LLC
Prouty Rebecca E.
Stole Einar
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