Chemistry: molecular biology and microbiology – Process of mutation – cell fusion – or genetic modification – Introduction of a polynucleotide molecule into or...
Patent
1999-03-25
2000-08-08
Wax, Robert A.
Chemistry: molecular biology and microbiology
Process of mutation, cell fusion, or genetic modification
Introduction of a polynucleotide molecule into or...
435189, 4352523, 43525411, 4353201, 435325, 435410, 435440, 536 232, C12N 1509, C12N 902, C12N 1529, C12N 514, C07H 2104
Patent
active
061000914
ABSTRACT:
Disclosed is a methods for modifying the chain length and double bond positional specificities of a soluble plant fatty acid desaturase. More specifically, the method involves modifying amino acid contact residues in the substrate binding channel of the soluble fatty acid desaturase which contact the fatty acid. Specifically disclosed is the modification of an acyl-ACP desaturase. Amino acid contact residues which lie within the substrate binding channel are identified, and subsequently replaced with different residues to effect the modification of activity.
REFERENCES:
patent: 5705391 (1998-01-01), Cahoon et al.
patent: 5888790 (1999-03-01), Cahoon et al.
Cahoon Edgar B.
Lindgvist Ylva
Schneider Gunter
Shanklin John
Bogosian Margaret C.
Brookhaven Science Associates
Stole Einar
Wax Robert A.
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