Modified 2′ and 3′-nucleoside prodrugs for...

Details Modified 2′ and 3′-nucleoside prodrugs for... Modified 2′ and 3′-nucleoside prodrugs for...

2007-03-20

2007-03-20

Lewis, Patrick (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S025000, C514S042000, C514S043000, C514S04400A, C514S050000, C536S027100, C536S028100, C536S028200

Reexamination Certificate

active

11005473

ABSTRACT:
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branchednucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.

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