Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1992-12-09
1996-03-05
Patterson, Jr., Charles L.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
534199, 5341723, C12P 2100, C12N 922
Patent
active
054967147
ABSTRACT:
The present invention is directed to modified proteins and methods of their production. The modified proteins comprise a controllable intervening protein sequence (CIVPS) inserted into a target protein, the CIVPS being capable of excision from the modified protein under predetermined conditions, i.e., increase in temperature, exposure to light, unblocking of amino acid residues by dephosphorylation or deglycosylation. If desired, the modified protein can be subjected to these conditions. The CIVPS may also be inserted into a region that substantially inactivates target protein activity.
REFERENCES:
Hirata et al., J. Biol. Chem. 256, 6726 (1990).
Kane et al., Science 250, 651 (1990).
Davis et al., J. Bact. 173, 5653 (1991).
Davis, et al. Cell, 71:201-210 (1992).
Perler, et al., PNAS 89, 5577 (1992).
Comb Donald G.
Hodges Robert A.
Jack William E.
Perler Francine B.
Xu Ming-Qun
Conlin David G.
New England Biolabs Inc.
Patterson Jr. Charles L.
Resnick David S.
Williams Gregory D.
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