Surgery – Radioactive substance applied to body for therapy
Reexamination Certificate
2007-03-20
2007-03-20
Lacyk, John P. (Department: 3735)
Surgery
Radioactive substance applied to body for therapy
C404S001000, C404S001000
Reexamination Certificate
active
09657701
ABSTRACT:
A radioactive source is made by forming a polymer layer substantially free of inorganic polymers on a substrate material, and exposing the polymer layer to a radioactive isotope. The source is useful for inhibition of restenosis in coronary arteries after balloon angioplasty or stent implantation. In particular, a radioactive source of32P,90Y, or144Ce is deposited on a poly(ethylene terephtalate) (PET) substrate. The polymer substrate was first coated with pH-sensitive hydrogel and then adsorbed various amount of phosphoric acid (PA) in aqueous solutions. The substrate was immersed in32P,90YCl3or144CeCl3solutions, and then32P,90Y or144Ce was deposited on the surface as32PPO4,90YPO4or144Ce PO4. Two different polyurethanes were used to encapsulate and seal the deposited isotopes on the surface to minimize the leakage of the isotope.
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Qu Xin
Weinberger Judah Z.
Cooper & Dunham LLP
Lacyk John P.
The Trustees of Columbia University in the City of New York
White John P.
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