Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Patent
1995-06-06
2000-01-25
Wax, Robert A.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
435 691, 43525233, 4353201, 4242401, 4242541, C07K 100, C12P 2106, A61K 39108, A61K 3910
Patent
active
060180226
ABSTRACT:
The three-dimensional structure of crystalline pertussis holotoxin (PT) has been determined by X-ray crystallography. Crystal structures have also been determined for complexes of pertussis toxin with molecules relevant to the biological activity of PT. These three-dimensional structures were analyzed to identify functional amino acids appropriate for modification to alter the biological properties of PT. Similar procedures may be used to predict amino acids which contribute to the toxicity of the holotoxin, to produce immunoprotective, genetically-detoxified analogs of pertussis toxin.
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Armstrong Glen D.
Cockle Stephen A.
Hazes Bart
Klein Michel H.
Loosmore Sheena
Connaught Laboratories Limited
Saidha Tekchand
University of Alberta
Wax Robert A.
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