Modification of methadone synthesis process step

Details Modification of methadone synthesis process step Modification of methadone synthesis process step

1976-05-10

1977-09-13

Brust, Joseph Paul

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07C12000, C07C12178

Patent

active

040482111

ABSTRACT:
Alkylation of diphenylacetonitrile in methadone synthesis is carried out in presence of sodium hydroxide and DMF.

REFERENCES:
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patent: 2574505 (1951-11-01), Sletzinger et al.
patent: 2607794 (1952-08-01), Chamberlin et al.
Schultz, et al., J.A.C.S., 69 (1947) 2454-2458.
Baizer, Bulletin on Narcotics, U.N. 5 (1), 32-43 (1953).
Cusic, J.A.C.S., 71 (1949) 3546.
Easton, et al., J.A.C.S., 69 (1947) 2941-2942.
Schultz, et al., J.A.C.S., 69 (1947) 188-189.
Cheney, et al., J.A.C.S., 71 (1949) 53-56.

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