Modification of cyclooxygenase and lipoxygenase activity...

Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from compositeae

Reexamination Certificate

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C424S725000

Reexamination Certificate

active

10732182

ABSTRACT:
Extracts from plants in the Asteridae subfamily, such asCarthamus tinctorious, are effective to selectively inhibit COX-2 activity and/or enhance COX-1 activity. When Asteridae extracts are combined with boswellic acid, the combination exhibits a synergistic inhibitory effect on both COX-2 and LO. Such extracts and combinations are used in methods of selectively inhibiting COX-2, inhibiting LO, and/or enhancing COX-1 activity as well as in the methods of treating conditions that would respond favorably to any of these effects.

REFERENCES:
patent: 4466923 (1984-08-01), Friedrich
patent: 5288725 (1994-02-01), Witherup et al.
patent: 5968519 (1999-10-01), Youssefyeh et al.
patent: 5972993 (1999-10-01), Ptchelintsev
patent: 6174876 (2001-01-01), Simmet et al.
patent: 6245340 (2001-06-01), Youssefyeh
patent: 6264995 (2001-07-01), Newmark et al.
patent: 6534086 (2003-03-01), Krumhar
patent: 6541045 (2003-04-01), Charters et al.
patent: 6746695 (2004-06-01), Martin et al.
patent: 2001/0024664 (2001-09-01), Obukowicz et al.
patent: 2004/0073060 (2004-04-01), Gokaraju et al.
patent: 0755940 (1997-01-01), None
patent: 2000014354 (2000-01-01), None
Akihisa et al.; “Triterpene Alcohols from the Flowers of Compositae and their Anti-inflammatory Effects”; Phytochemistry, vol. 43, No. 6, pp. 1255-1260, 1996.
Ammon, H.,Boswellic Acids(Components of Frankincense)as the Active Principle in Treatment of Chronic Inflammatory Diseases, Wien Med Wochenschr., 152(15-16):373-8 (2002) (Abstract).
Cassileth and Yeung,Boswellia, Brainlife Brain Tumor Medical Database, 3 pp. (last updated Jan. 13, 2003) <http://www.brainlife.org/education/integrative/supplements/boswellia/cassileth—boswellia.htm>.
Hong et al.,Inhibitory Effect of a Korean Traditional Medicine, Honghwain-Jahage(Water Extracts of Carthamus tinctorius L. Seed and Hominis placenta)on Interleukin-1-Mediated Bone Resorption, J. Ethnopharmacol., 79(2):143-148 (2002) (Abstract).
Kee Chang Huang, The Pharmacology of Chinese Herbs, 318-320 (2thed. 1999).
Kimmatkar et al.,Efficacy and Tolerability of Boswellia serrata Extract in Treatment of Osteoarthritis of Knee—A Randomized Double Blind Placebo Controlled Trial, Phytomedicine, 10(1):3-7 (2003).
Li and Che,Studies on Chemical Components of Carthamus tinctorius petals, Yao Xue Xue Bao, 33(8):626-8 (1998) (Abstract).
Lin et al.,Anti-Inflammatory and Radical Scavenge Effects of Arctium lappa, Am. J. Chin. Med., 24(2):127-37 (1996) (Abstract).
Ruppelt et al.,Pharmacological Screening of Plants Recommended by Folk Medicine as Anti-Snake Venom—I. Analgesic and Anti-Inflammatory Activities, Mem. Inst. Oswaldo Cruz, 86(2):203-5 (1991) (Abstract).
Safayhi et al.,Boswellic Acids: Novel, Specific, Nonredox Inhibitors of 5-Lipoxygenase, J. Pharmacol. and Exper. Ther., 261(3):1143-1146 (1992).
Singh et al.,Pharmacology of an Extract of Salai Guggal ex-Boswellia Serrata, a new Non-Steroidal Anti-Inflammatory Agent, Agents Actions, 18(3-4):407-12 (1986) (Abstract).
Yuk, et al.,Inhibitory Effect of Carthamus tinctoris L. Seed Extracts on Bone Resorption Mediated by Tyrosine Kinase, COX-2(Cyclooxygenase)and PG(Prostaglandin)E2, Am. J. Chin. Med., 30(1):95-108 (2002) (Abstract).

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