Models for measuring the sense of smell

Details Models for measuring the sense of smell Models for measuring the sense of smell

1996-10-23

1999-03-09

Campell, Bruce R.

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

800DIG1, 4351723, 424 91, C12N 500, C12N 1500, A61K 4900

Patent

active

058803262

ABSTRACT:
The invention provides methods and compositions for measuring the sense of smell, including animals having general anosmia as a result of a genetic mutation. The genetic mutation disrupts a function of a protein required for cyclic nucleotide mediated signal transduction in olfactory neurons in the animal. The invention also encompasses methods of making and using such animals, such as methods of characterizing the effect of a stimulus on the subject mutant animals by contacting the animal with a stimulus and measuring a response of the animal to the stimulus, wherein the presence of a response indicates that the stimulus evokes a non-olfactory response.

REFERENCES:
M Barinaga (1996) Science 274: 500-501.
H Komatsu et al (1996) Neuron 17: 707-718.
P Sengupta et al (1994) Cell 79: 971-980.
RL Davis et al (1995) Molecular and Cellular Biochemistry 149/150:271-278.
M Cobb (1996) Genetics 144: 1577-1587.

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