Model rat with the onset of prostatic cancer

Details Model rat with the onset of prostatic cancer Model rat with the onset of prostatic cancer

2006-09-12

2006-09-12

Crouch, Deborah (Department: 1632)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

C800S003000, C800S021000

Reexamination Certificate

active

07105717

ABSTRACT:
To provide a rat model with the onset of prostate cancer in which the prostate cancer including an invasive cancer can be developed and can be bred for generations stably. A rat model with the onset of prostate cancer which can develop prostate cancer including invasive cancer and can be bred for generations stably is established by: ligating an SV40 large T antigen gene onto the downstream of rat probasin gene promoter; the resulting PBSVT transgene is introduced into a fertilized egg of a Sprague-Dawley rat; after the introduction, the fertilized egg is transplanted into a recipient rat; a transgenic rat obtained from the recipient rat is then mated with a wild-type Sprague-Dawley rat; the transgenic offspring rats thus obtained are similarly can be bred for generations thereafter; and transgenic rats developing prostate cancer are selected through histopathological observation of the prostate.

REFERENCES:
patent: 5907078 (1999-05-01), Greenberg et al.
Navone et al. (1999) Model Systems of prostate Cancer: USes and Limitations. Cancer and Metastatsis Reviews. 17:361-371.
Drago et al. (1980) The Nb rat prostatic adenocarcinoma model system. Prog. Clin. Biol. Res. 37:265-91. (Abstract only).
T. Shirai, et al.Rat Prostate As One of the Target Organs for 3,2′-Dimethyl-4-aminobiphenyl-Induced Carcinogenesis: Effects of Dietary Ethinyl Estradiol and Methyltestosterone. Jpn. J. Cancer Res., vol. 76, pp. 803-808, Sep. 1985.
T. Shirai, et al.Induction of Invasive Carcinomas in the Accessory Sex Organs Other Than the Ventral Prostate of Rats Given 3,2′-Dimethyl-4-aminobuphenyl and Testosterone Propionate. Cancer Research. vol. 51, pp. 1264-1269, Feb 15, 1991.
T. Shirai, et al.Duration dependent induction of invasive prostatic carcinomas with pharmacological dose of testosterone propionate in rats pretreated with 3,2′-dimethyl-4-aminobiphenyl and development of androgen-independent carcinomas after castration. Cancer Letters. vol. 83, pp. 111-116, 1994.
T. Shirai, et al.Site-specific Effects of Testosterone Propionate on the Prostate of Rat Pretreated with 3,2′-Dimethyl-4-aminobiphenyl: Dose-dependent Induction of Invasive Carcinomas. Jpn. J. Cancer Res., vol. 86, pp. 645-648, Jul. 1995.
T. Masui, et al.Ki-ras Mutations With Frequent Normal Allele Loss Versus Absence of p. 53 Mutations in Rat Prostate and Seminal Vesicle Carcinomas Induced With 3,2′-Dimethyl-4-aminobiphenyl. Molecular Carcinogenesis. vol. 13, pp. 21-26, 1995.
H. Nakanishi, et al.Establishment and Characterization of Three Androgen-independent, Metastatic Carcinoma Cell Lines from 3,2′-Dimethyl-4-aminobiphenyl-induced Prostatic Tumors in F344 RatsJpn. J. Cancer Res. vol. 87, pp. 1218-1226, Dec. 1996.
K. Kato, et al.Establishment of Transplantable Rat Prostate Carcinomas from Primary Lesions Induced by 3,2′-Dimethyl-4-aminobiphenyl and Testosterone. J. Toxicol. Pathol., vol. 11, pp. 27-32, 1998.
S. Iwasaki, et al.,Development of Androgen-independent Carcinomas from Androgen-dependent Preneoplastic Lesions in the male Accessory Sex Organs of Rats Treated with 3,2′-Dimethyl-4-aminobiphenyl and Testosterone Propionate. Jpn. J. Cancer Res., vol. 90, pp. 23-30, Jan. 1999.
J.W.Gordon, et al.,Genetic transformation of mouse embryos by microinjection of purified DNA. Proc. Natl. Acad. Sci. USA. vol. 77, No. 12, pp. 7380-7384, Dec. 1980.
Y. Toyoda, et al.,Fertilization of Rat Eggs IN VITRO By Epididymal Spermatozoa and the Development Eggs Following Transfer. J. Reprod. Fert., vol. 36, pp. 9-22, 1974.
Nihon gan gakkai soukai kiji (Article on the 58thAnnual Meeting of Japanese Cancer Association), p. 406, 1999.
B. Charreau, et al.Transgenesis in rats:technical aspects and models. Transgenic Research. vol. 5, pp. 223-234, 1996.
Proceedings of the American Association for Cancer Research, Abstracts, vol. 41, p. 47, Mar. 2000.
Annual Meeting Abstracts., Laboratory Investigation, vol. 76, No. 1, p. 70A, 1997.
S. Kasper, et al.,Development, Progression, and Androgen-Dependence of Prostate Tumors in Probasin-Large T-Antigen Transgenic Mice: A Model for Pŕostate Cancer. Laboratory Investigation. vol. 78, No. 3, pp. 319-333, 1998.
J. E. Green, et al.,Workgroup 3: Transgenic and Reconstitution Models of Prostate Cancer. The Prostate. vol. 36, pp. 59-63, 1998.
S. Hochi, et al.,Successful Production of Transgenic Rats. Animal Biotechnology. vol. 1, No. 2, pp. 175-184, 1990.
S.V. Garde, et al.,A comparative study on expression of prostatic inhibin peptide, prostate acid phosphatase and prostate specific antigen in androgen independent human and rat prostate carcinoma cell lines. Cancer Letters. vol. 70, pp. 159-166, 1993.
Takahashi et al., “Tumor development in transgenic rats harboring probasin gene promoter/SV40 T antigen fusion gene,” Nihon gan gakkai soukai kiji (Article on the 58thAnnual Meeting of Japanese Cancer Association), p. 406, Aug. 30, 1999.
Greenberg et al., “Prostate Cancer in a Transgenic Mouse,” Proc. Natl. Acad. Sci., vol. 92, pp. 3439-3443, Apr. 1995.
Patent Abstracts of Japan, English language abstract of JP 11-313575, published Nov. 16, 1999.
Greenberg et al., “Prostate Cancer in a Transgenic Mouse,” Proc. Natl. Acad. Sci., vol. 92, pp. 3439-3443, Apr. 1995.
Patent Abstracts of Japan, English language abstract of JP 11-313575, published Nov. 16, 1999.

Affiliated with

Also associated with

Rating

Model rat with the onset of prostatic cancer does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Model rat with the onset of prostatic cancer, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Model rat with the onset of prostatic cancer will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3558349