Model of infantile spasm syndrome

Details Model of infantile spasm syndrome Model of infantile spasm syndrome

2011-01-04

2011-01-04

Wehbe, Anne Marie S (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

The nonhuman animal is a model for human disease

C800S008000, C424S009200

Reexamination Certificate

active

07863499

ABSTRACT:
Provided are non-human mammals treated with doxorubicin, lipopolysaccharide (LPS), and p-chlorophenylalanine (PCPA), where the mammal exhibits a symptom characteristic of infantile spasms. Also provided are methods of making a non-human mammal exhibit a symptom of infantile spasms. Additionally, methods are provided for screening a compound for the potential to attenuate a symptom of infantile spasms.

REFERENCES:
Siegal et al. (1988), J. Neuro-Oncol., vol. 6, 135-140.
Stafstrom et al. (2006) Epilepsia, vol. 47 (8), 1407-1414.
Stafstrom and Holmes (2002) Int. Rev. Neurobiol., vol. 49, 391-410.
Lee CL et al. A new animal model of infantile spasms wth unprovoked persistent seizures. Epilepsia, 2007, Oct. 18, pp. 1-10 [Epub].
Pang Y et al., entitled “Disturbance of oligodendrocyte development, hypomyelination and white matter injury in the neonatal rat brain after intracerebral injection of lipopolysaccharide,” Developmental Brain Research, 14, 2003, pp. 205-214.
Pflieger J F et al., entitled “Postural Modifications and Neuronal Excitability Changes Induced by a Short-Term Serotonin Depletion during Neonatal Development in the Rat,” The Journal of Neuroscience, Jun. 15, 2002, 22(12), pp. 5108-5117.
Scantlebury MH et al. A New Animal of Infantile Spasms. American Epilepsy Society Abstract, 2006, 2 pages.
Siegal T et al., entitled “Early and delayed neurotoxicity of Mitoxantrone and Doxorubicin following subarachnoid injection,” Journal of Neuro-Oncology 6, 1988, pp. 135-140.
Stafstrom C E et al., entitled “Infantile Spasms: Criteria for an Animal Model,” International Review of Neurobiology, 2002, vol. 49, pp. 391-410.
Stafstrom C E et al., entitled “Models of pediatric epilepsies: strategies and opportunities,” Epilepsia, 2006, Aug. 47, 8, pp. 1407-1414.
Velisek L et al., entitled “Model of Infantile Spasms Induced by N-Methyl-D-Aspartic Acid in Prenatally Impaired Brain,” Ann Neurol 2007, 61, pp. 109-119.

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