Model for protective and pathogenic roles of HIV-1 env-directed

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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436506, 514 44, 5303894, 5303896, 435 724, 435 29, 435 39, 435810, 435974, C12Q 170, G01N 33564, A01N 4304, C07K 1600

Patent

active

061070203

ABSTRACT:
Methods and kits for diagnosing the presence of and prognosing the of stages of HIV disease, involving correlating rate of CD4% decline, CMC activity and plasma HIV RNA load, are disclosed. In particular, the methods and kits pertain to diagnosis and prognosis of disease progression in retroviral infections.

REFERENCES:
Ellaurie, M. et al. (1990) "Human Immunodeficiency Virus (HIV) Circulating Immune Complexes in Infected Children" AIDS Res. Hum. Retro.; 6(12):1437-41.
Ho, D. (1996) "Viral Counts Count in HIV Infection" Science; 272:1124-25.
Kovacs, J.A. (1995) "Increases in CD4 T Lymphocytes with Intermittent Courses of IL-2 in Patients with Human Immunodeficiency Virus Infection" N. Eng. J. Med.; 332:567-575.
Levy, J. et al. (1994) "Passive Hyperimmune Plasma Therapy in the Treatment of Acquired Immunodeficiency Syndrome: Results of a 12-month Multicenter Double-Blind Controlled Trial" Blood; 84(7):2130-35.
Pennisi, E. et al. (1996) "Eradicating HIV From a Patient: Not Just a Dream?" Science; 272:1884.
Schechter, M.T. et al. (1990) "Susceptibility to AIDS Progression Appears Early in HIV Infection" AIDS; 4:185-90.
Skowron, G. (1994) "HIV-1 env-Specific Cellular Cytotoxicity in HIV-1-Seropositive Mothers and Their Infants" AIDS Research and Human Retroviruses; 10(Suppl. 2):S79-82.

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