Model animal causing the white hair development and methods...

Details Model animal causing the white hair development and methods... Model animal causing the white hair development and methods...

2006-02-10

2011-11-29

Kaushal, Sumesh (Department: 1633)

Multicellular living organisms and unmodified parts thereof and

Nonhuman animal

Transgenic nonhuman animal

C800S004000, C800S008000, C800S009000, C800S014000, C800S021000, C435S069100, C435S320100, C435S325000, C435S455000

Reexamination Certificate

active

08067666

ABSTRACT:
A model rodent animal with a phenotype in which hair growing after birth is black, with the animal spontaneously developing white hair after aging. By way of example, the model rodent animal may have a genotype in which an activated RET gene is genetically inserted in a heterozygous form and the endothelin receptor B gene is deficient in a heterozygous form.

REFERENCES:
patent: 7105717 (2006-09-01), Shirai et al.
patent: 9-131146 (1997-05-01), None
patent: 2001-231402 (2001-08-01), None
Matsushima et al. Mammalian Genome 13:30-35; 2002.
Kato et al. Oncogene 17: 1885-1888; 1998.
Kumasaka et al. Cancer Res. 70:24-29; 2010.
Slominski et al Journal of Investigative Dermatology 124:13-21, 2005.

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