Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Patent
1997-05-30
1999-08-03
Beisner, William H.
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
204452, G01N 2726
Patent
active
059320800
ABSTRACT:
Identification and quantification of constituents of a sample is achieved by mobility-based electropherograms obtained from capillary electrophoresis, the mobilities being normalized by zero correction followed by division by the mobility of a selected marker. Zero correction is achieved either relative to a separate marker or by calculation based on the same marker. The resulting electropherograms are more recognizable since they more closely resemble the scanned separation patterns obtained with planar gels, and individual constituents of the sample are more easily and reliably identified since their positions in the electropherogram are substantially constant from one electropherogram to the next and hence reproducible to a high degree of accuracy.
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Ju Yang et al., "Improved Reproducibility in Capillary Electrophoresis Through the Use of Mobility and Migration Time Ratios," Journal of Chromatography A (1996) 735: 209-220.
J.L. Beckers et al., "Determination of Absolute Mobilities, pK Values and Separation Numbers by Capillary Zone Electrophoresis, Effective Mobility as a Parameter for Screening," Journal of Chromatography (1991) 537: 407-428.
Beisner William H.
Bio-Rad Laboratories, Inc.
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