Mobile phase gradient generation microfluidic device

Details Mobile phase gradient generation microfluidic device Mobile phase gradient generation microfluidic device

2006-11-21

2006-11-21

Therkorn, Ernest G. (Department: 1723)

Liquid purification or separation

Processes

Chromatography

C210S101000, C210S198200

Reexamination Certificate

active

07138062

ABSTRACT:
The present invention relates to a microfluidic device for separating the components of a fluid sample. A cover plate is arranged over the first surface of a substrate, which, in combination with a microchannel formed in the first surface, defines a separation conduit for separating the components of the fluid sample. An inlet port in fluid communication with the separation conduit allows a mobile phase containing a gradient of a selected mobile-phase component to be introduced from an integrated gradient-generation means to the separation conduit. A method is also provided for separating the components of a fluid sample using a mobile phase containing a gradient of a selected mobile-phase component, wherein the gradient is generated within a small volume of mobile phase.

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