MNTF peptides and compositions and methods of use

Details MNTF peptides and compositions and methods of use MNTF peptides and compositions and methods of use

2007-02-27

2007-02-27

Tate, Christopher R. (Department: 1654)

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

C530S326000, C530S327000, C530S328000, C530S329000, C514S012200

Reexamination Certificate

active

10541343

ABSTRACT:
The present invention is directed to novel peptides and compositions capable of modulating viability and growth in neuronal cells, and to methods of modulating neuronal cell viability and growth employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to novel peptide analogues of motoneuronotrophic factor 1 containing either a “WMLSAFS” or “FSRYAR domain,” which is sufficient for neurotrophic or neurotropic function.

REFERENCES:
patent: 6309877 (2001-10-01), Chau
patent: 6759389 (2004-07-01), Chau
patent: 6841531 (2005-01-01), Chau
U.S. Appl. No. 10/858,545, filed Nov. 11, 2004, Chau.
U.S. Appl. No. 10/858,286, filed Dec. 2, 2004, Chau.
U.S. Appl. No. 10/858,543, filed Dec. 30, 2004, Chau.
Chau, R.M.W. et al:“Muscle neurotrophic factors specific for anterior hom motoneurons of rat spinal cord.” Recent Advances in Cellular & Molecular Biology, vol. 5,1992, 89-94.
Zhou, Minghua et al; “Production and assessment of MAB specific for the 35kD MNTF from rat skeletal muscle.” J. Monoclonal Antibody 1992. vol. 8(3), 40-44.
Yu, W.H.A. et al: “Muscle-derived Motoneuronotrophic factors promote survival of axontomized motoneurons on the facial nerve.” Society for Neuroscience 22nd Ann.Mtg 1992, #546.
Chau, R. et al: “Synergetic effect of MNTF 1 & 2 on survival of axontomized motoneurons of sciatic nerve.” 22nd Ann. Mtg. Of the Society for Neuroscience, 1992, vol. 18, #546.
Chau, R et al: “Effect of 22kD, 35kD molecules from skeletal muscle extract on ant. hom motoneuron of lumbar spine in rat.” Chinese Science Bulletin, 1992, 37(2); 1742-1745.
Chau, R.M.W. et al,: “Cloning of genes from MNTF1 and its receptor by monoclonal antibody probes.” Society for Neuroscience Abstracts, vol. 19, 1993, p. 252, #109.23.
Zhou, Minghua et al: “Changes in MNTF and its receptor in tongue muscle post-denervation of the hypoglossal nerve.” Acta Anatomica Sinica, vol. 24, No. 4, Oct. 1993, 391-395.
Zhang, Nanling et al: “Immunohistochemical localization of muscle-derived motoneuronotrophic factor 1 & its receptor in the stomach of rat.” Jiepou Xuebao (1994),25(1), 56-58.
Zhou, Ming-Hua (Chau, R.M.W.) et al: “Immunohistochemical localization of Motoneuronotrophic factor in fetal and neonatal rats.” Jiepou Xuebao (1994), 25(2), 189-192.
* Full text in Chinese, English translation for abstract only.
Chau, R.et al: “Effects of 22, 35 kD MNTF of axonal regeneration in peripheral nerve autografts in rat spinal cord.” Chinese J. of Spine & Spinal Cord, 1995, 5(6): 248-252.
Chau, R.M.W. et al,: “Biological effect of MNTF on wobbler mice with motoneuron disease” 25th Annual Meeting of the Society for Neuroscience, vol. 22 No. 1-3, 1996, 233.
Zhou, Ming-Hua et al: “Distribution of MNTF1 in spinal cord and limb muscles of mice with motoneuron disease” Acta Academiae Medicinae Sinicae vol. 19, No. 3, Jun. 1997,171-178.
Di, Xinyu et al:“Immunohistochemical localization of c-fos, p53 protein & MNTF 1 receptor in early human placental villi.” Jiepou Xuebao vol. 28, No. 4, 404-406, Oct. 1997.
Di, Xinyu et al: “Localization & morphometric study on MNTF 1 & its receptor in developing chronic villi of human placenta.” Jiepou Xuebao, vol. 29 No. 1, 86-89, Jan. 1998.
Nussbaum, D., Brushart, T. et al: “Motoneuron Trophic Factor (MNTF) from gene to function.” 2003 Society for Neuroscience Annual Meeting Poster #357.19.
* Full text in Chinese, English translation for abstract only.

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