Mnk1 or Mnk2 inhibitors

Details Mnk1 or Mnk2 inhibitors Mnk1 or Mnk2 inhibitors

2005-12-22

2011-12-06

Murray, Jeffrey (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

Reexamination Certificate

active

08071607

ABSTRACT:
The present invention relates to the use of pyrazolopyrimidine compounds for the production of pharmaceutical compositions for the prophylaxis and/or treatment of diseases which can be influenced by the inhibition of the kinase activity of Mnk1 and/or Mnk2 (Mnk2aor Mnk2b) and/or variants thereof.

REFERENCES:
patent: 408945 (1966-03-01), None
patent: WO2004/037159 (2004-05-01), None
patent: WO2004/106340 (2004-12-01), None
Wolff et. al., “Burger's Medicinal Chemistry and Drug Discovery,” 5th Ed. Part 1, pp. 975-977 (1995).
http://www.medterms.com/script/main/art.asp?articlekey=12063, last accessed on Aug. 24, 2010.
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.
Banker, et. al., Modern Pharmaceuticals, p. 596.
Cheng, et al., “Potential Purine Antagonists, VI.”, Journal of Organic Chemistry, American Chemical Society, Easton, US, vol. 21, Nov. 1, 1956, pp. 1240-1256.
Young, et al., “Purine Derivatives as Competitive Inhibitors of Human Erythrocyte Membrane Phosphatidylinositol 4-Kinase”, Journal of Medicinal Chemistry, American Chemical Society. Washington, US, vol. 33, No. 8 Aug. 1, 1990, pp. 2073-2080.
Peat, et al., “Novel Pyrazolopyrimidine Derivatives as GSK-3 Inhibitors.” Bioorganic & Medicinal Chemistry Letters. May 3, 2004, vol. 14, No. 9, pp. 2121-2125.
Traxler et al., “Use of a Pharmacophore Model for the Design of EGF-R Tyrosine Kinase Inhibitors: 4-(Phenylamino)Pyrazolo3,4-Dpyrimidines”, Journal of Medicinal Chemistry, American Chemical Society, Washington, US, vol. 40, No. 22, 1997, pp. 3601-3616.

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