Mnk kinase homologous proteins involved in the regulation of...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving transferase

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

08076098

ABSTRACT:
The present invention discloses Mnk homologous proteins regulating the energy homeostasis, the metabolism of triglycerides, and/or is contributing to membrane stability and/or function of organelles, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to the use of these sequences in the diagnosis, study, prevention, and treatment of diseases and disorders related to body-weight regulation and thermogenesis, for example, but not limited to, metabolic diseases such as obesity, as well as related disorders such as eating disorder, cachexia, diabetes mellitus, hypertension, coronary heart disease, hypercholesterolemia, dyslipidemia, osteoarthritis, gallstones, and sleep apnea, and disorders related to ROS defence, such as diabetes mellitus, neurodegenerative disorders, and cancer, e.g. cancers of the reproductive organs, and others.

REFERENCES:
patent: 5658903 (1997-08-01), Adams et al.
patent: 5786356 (1998-07-01), Bell et al.
patent: 5932576 (1999-08-01), Anantanarayan et al.
patent: 5981533 (1999-11-01), Traxler et al.
patent: 0 819 129 (1998-01-01), None
patent: 601 85719 (1985-09-01), None
patent: WO 89/11295 (1989-11-01), None
patent: WO 95/06411 (1995-09-01), None
patent: WO 98/25908 (1998-06-01), None
patent: WO 99/02532 (1999-01-01), None
patent: WO 02/055664 (2002-07-01), None
patent: WO 02/103361 (2002-12-01), None
Waskiewicz, AJ et al., EMBO J 16(8): 1909-1920, 1997.
Knauf et al., “Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2”, Molecular and Cellular Biology, Aug. 2001, pp. 5500-5511, vol. 21, No. 16.
Waskiewicz et al., “Phosphorylation of the Cap-Binding Protein Eukaryotic Translation Initiation Factor 4E by Protein Kinase Mnk1 in Vivo”, Molecular and Cellular Biology, Mar. 1999, pp. 1871-1880, vol. 19, No. 3.
Slentz-Kesler K. et al., “Identification of the human Mnk2 Gene (MKNK2) through Protein Interaction with Estrogen Receptor Beta”, Genomics, vol. 69, No. 1, Oct. 1, 2000, pp. 63-71.
Fukunaga R et al.: Mnkl, a new map kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates, EMBO Journal, Oxford University Press, Surrey, GB, vol. 16, No. 8, 1997, pp. 1921-1933, XP000887346.
Slentz-Kesler K et al.: Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta, Genomics, Academic Press, San Diego, US, vol. 69, No. 1, Oct. 1, 2000, pp. 63-71, XP002221149.
Database CA Online Chemical Abstracts Service, Columbus, Ohio, US; Li Nenggan et al.: Protein and cDNA sequence of a novel human protein kinase Mnk2, retrieved from STN Database accession No. 136: 19531 8 HCA, XP002246761 & CN 1 301 870 (Nanfang Research Center, State Human Genome Project, Peop. Rep. China) Jul. 4, 2001.
Database Biosis Online Biosciences Information Service, I Philadelphia, PA, US, Apr. 2000, Tschopp et al.: Phosphorylation of elF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies, Database accession No. PREV200000389084, XP002246762 cited in the application abstract & Molecular Cell Biology Research Communications, vol. 3, No. 4, Apr. 2000, pp. 205-211.
Eatabase Biosis Online Biosciences Information Service, Philadelphia, PA, US, Aug. 2001, Knaiif Ursula et al.: Negative regulation of protein translation by mitogen-activated protein kinaseinteracting kinases i and 2, Database accession No. PREV200100384691, XP002246763 cited in the application abstract & Molecular Cellular Biology, vol. 21, No. 16, Apr. 2001, pp. 5500-551 1.
Waskiewicz, A.J. et al.: Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase MnkI in vivo, Mol. Cell. Biol., 1999, vol. 19, pp. 1871-1880.
Wikipedia “Aptamer”Wikipedia “Aptamer” , Jul. 5, 2010.
Tsukiyama-Kohara et al.: Mature Medicine, Oct. 1, 2001, vol. 7, No. 10, pp. 1 128-1 132.
Scheper, Gert C et al.: The mitogen-activated protein kinase signal-integrating kinase Mnk2 is / eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells, Mol. Cell. Biol. Feb. 2001, vol. 21, No. 3, p. 743-754.
Jauch et al.: Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site, Structure, vol. 13, / 1559-1568, Oct. 2005.
Kordik et al.: Pyrazolecarboxamide human neuropeptide Y5 receptor ligands with in vivo antifeedant activity, Bioorganic & Medicinal Chemistry Letters 11 (2001) 2287-2290.
Tocris bioscience.
Extract of the “Lexikon der Biochemie”, SpeMrum Akademischer Verlag Heidelberg, 1999.
Waskiewicz, et al. “Mitogen-activated protein kinases activate the serine/theronine kinases Mnk1 and Mnk2”, The EMBO Journal vol. 16, No. 8, pp. 1909-1920, 1997.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Mnk kinase homologous proteins involved in the regulation of... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mnk kinase homologous proteins involved in the regulation of..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mnk kinase homologous proteins involved in the regulation of... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-4253613

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.