MN gene and protein

Details MN gene and protein MN gene and protein

1997-01-24

2000-02-22

Jones, W. Gary

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

536 231, 536 243, C12Q 168, C07H 2102, C07H 2104

Patent

active

060278870

ABSTRACT:
Herein disclosed is a novel oncogene named MN or alternatively MN/CA IX. The MN protein has been determined to be the first tumor-associated carbonic anhydrase isoenzyme that has been described. Abnormal expression of the MN gene is shown to signify oncogenesis, and diagnostic/prognostic methods for pre-neoplastic
eoplastic disease to detect or detect and quantitate such abnormal MN gene expression, e.g., immunoassays and nucleic acid hybridization assays, are provided. Also disclosed are methods to treat pre-neoplastic
eoplastic disease involving the MN gene and protein, e.g., methods comprising the use of MN-specific antibodies, conjugated or unconjugated to cytotoxic agents, and the use of MN antisense nucleic acids.

REFERENCES:
patent: 5219727 (1993-06-01), Wang et al.
patent: 5387676 (1995-02-01), Zavada et al.
patent: 5585479 (1996-12-01), Hoke et al.
patent: 5589579 (1996-12-01), Torczynski et al.
patent: 5591826 (1997-01-01), De La Chapelle
patent: 5643729 (1997-07-01), Taniguchi et al.
patent: 5710001 (1998-01-01), Skolnick
patent: 5773579 (1998-06-01), Torczynski et al.
Uemura et al., "Expression of Tumor-Associated Antigen MN/G250 in Urologic Carcinoma: Potential Therapeutic Target," J. Urology: 157 (4 Supp): 377 (Abstract 1475) (Apr. 16, 1997).
Inoue et al., Blood 84(9): 3071-3079 (1994).
Murty et al., Oncogene 9: 3227-3231 (1994).
Anton et al., "Localized renal-cell carcinoma: detection of abnormal cells in periturmoal tissue. A cytophotometry and immunocytochemistry study," World J. Urol., 13(3): 149-152 (1995).
Bander et al., "Renal cancer imaging with monoclonal antibody G250," J. Urol., 155 (5 Suppl.): 583A (Abstract 1088) (1996).
Brewer et al., "A Study of Biomarkers in Cervical Carcinoma and Clinical Correlation of the Novel Biomarker MN," Gynecologic Oncology, 63, 337-344 (1996).
Costa, M., "MN and Ki67 (MIB-1) in Uterine Cervix Carcinoma: Novel Biomarkers With Divergent Utility," Human Pathology, 27(3): 217-219 (Mar. 1996).
Divgi et al., "Scintigraphy of Renal Cell Carcinoma with I-131 Labelled Monoclonal Antibody (MAB) G250," European Journal of Nuclear Medicine, 19 (8): 578 (Abstract 121-3) (Aug. 23, 1992).
Frosham et al., "Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer," PNAS (USA), 85: 8998-9002 (Dec. 1988).
Frosch et al., "Cloning and characterization of an immunodominant major surface antigen of Echinococus multilocularis," Molecular and Biochemical Parasitology, 48: 121-130 (1991).
Kranenborg et al., "Development and Characterization of Anti-Renal Cell Carcinoma X Antichelate Bispecific Monoclonal Antibodies for Two-Phase Targeting of Renal Cell Carcinoma," Cancer Res., 55 (23 Suppl.) 5864s-5867s (1995).
Kurth et al., "Characterization of Human Renal Cell Carcinoma Tumor Lines by Means of Monoclonal Antibodies," Prostate, 6(4): 451 (Abstract) (1985).
Liao and Stanbridge, "Expression of the MN Antigen in Cervical Papanicolaou Smears Is an Early Diagnostic Biomarker of Cervical Dysplasia," Cancer Epidemiology, Biomarkers & Prevention, 5: 549-557 (Jul. 1996).
Liao et al., "Identification of the MN Antigen as a Diagnostic Biomarker of Cervical Intraepithelial Squamous and Glandular Neoplasia and Cervical Carcinomas," American Journal of Pathology, 145(3): 598-609 (Sep. 1994).
Luiten et al., "Target-Specific Activation of Mast Cells by Immunoglobulin E Reactive with a Renal Cell Carcinoma-Associated Antigen," Laboratory Investigation, 74(2): 467-475 (1996).
Luiten et al., "Generation of chimeric bispecific G250/anti-CD3 monoclonal antibody, a tool to combat renal cell carcinoma," British Journal of Cancer, 74(5): 735-744 (1996).
Luner et al., "Monoclonal Antibodies to Kidney and Tumor-associated Surface Antigens of Human Renal Cell Carcinoma," Cancer Res., 46(11): 5816-5820 (1986).
Moon et al., "A Highly Restricted Antigen for Renal Cell Carcinoma Defined by a Monoclonal Antibody," Hybridoma, 4(2): 163-172 (1985).
Oosterwijk and Debruyne, "Radiolabeled monoclonal antibody G250 in renal-cell carcinoma," World Journal of Urology, 13: 186-190 (1995).
Oosterwijk et al., "The Expression of Renal Antigens in Renal Cell Carcinoma," World Journal of Urology, 2(2): 156-158 (1994).
Oosterwijk et al., "Monoclonal Antibodies that Discriminate Between Renal Cell Carcinomas (RCC) and Other Malignancies," Prostate, 6(4): 451-452 (Abstract) (1985).
Oosterwijk et al., "Immunohistochemical Analysis of Monoclonal Antibodies to Renal Antigens--Application in the Diagnosis of Renal Cell Carcinoma," American Journal of Pathology, 123(2): 301-309 (May 1996).
Oosterwijk et al., "Monoclonal Antibody G250 Recognizes a Determinant Present in Renal-Cell Carcinoma and Absent from Normal Kidney," Int. J. Cancer, 38: 489-494 (1986).
Oosterwijk et al., "Relationship between DNA Ploidy, Antigen Expression and Survival in Renal Cell Carcinoma," Int. J. Cancer, 42: 703-708 (1988).
Oosterwijk et al., "Expression of Intermediate-sized Filaments in Developing and Adult Human Kidney and Renal Cell Carcinoma," The Journal of Histochemistry and Cytochemistry, 38 (3): 385-392 (1990).
Oosterwijk et al., "Antibody Localization in Human Renal Cell Carcinoma: A Phase I Study of Monoclonal Antibody G250," Journal of Clinical Oncology, 11(4): 738-750 (Apr. 1993).
Oosterwijk et al., "The Use of Monoclonal Antibodiy G250 in the Therapy of Renal-Cell Carcinoma," Seminars in Oncology, 22 (1): 34-41 (Feb. 1995).
Oosterwijk et al., Molecular characterization of the Renal Cell Carcinoma-associated antigen G250, Proceedings of the American Association for Cancer Research, 37: 461 (Abstract #3147) (Mar. 1996).
Opavsky et al., "Regulation of MN Expression," Cell Biology International, 18(5): Abstract No. Mo-58 (1994).
Opavsky et al., "Human MN/CA9 Gene a Novel Member of the Carbonic Anhydrase Family: Structure and Exon to Protein Domain Relationships," Genomics, 33: 480-487 (1996).
Pasotrek et al., "The Structure and Expression of MN Gene, Coding for a Tumor-Associated Protein p54/58N," J. Cancer Res., Clin. Oncol, 119 (Suppl. 1) 10/113 (1993).
Pastorek et al., "Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment," Oncogene, 9, 2877-2888 (1994).
Pastorek et al., "MN--A Novel Type of Oncoprotein," Cell Biology International, 18(5): Abstract No. Mo-57 (1994).
Pastorek et al., "A Novel Quasi-viral Agent, MaTU, Is a Two-Component System," Virology, 187: 620-626 (1992).
Pastorekova e tal., "Transformation of Mammalian Cells by MN Oncogene," Cell Biology International, 18(5): Abstract No. Mo-56 (1994).
Pastorekova et al., "MN/CA IX, a Carbonic Anhydrase Isoenzyme Implicated in Carcinogenesis," Abstract submitted to International Conference on Experimental and Clinical Oncology, Greece (Oct. 3-5, 1996).
Saarino et al., "Distribution of carbonic anhydrase isoenzymes I, II, IV, V, VI and MN/CA IX in the human intestine. An immunohistochemical study," Abstract submitted to to the meeting for United European Gastroenterological Week, Paris (Nov. 2-6, 1996).
Steffens et al., "Radioimmunotargeting with I.sup.131 labeled chimeric G250 monoclonal antibody in patients with renal cell carcinoma," J. Nucl. Med., 37 (5 Suppl.): 169P (1996).
Surfus et al., "Anti-Renal-Cell Carcinoma Chimeic Antibody G250 Facilitates Antibody-Dependent Cellular Cytotoxicity with In Vitro and In Vivo Interleukin-2-Activated Effectors," Journal of Immunotherapy 19 (3): 184-191 (1996).
Tweedie and Edwards, "Mouse Carbonic Anhydrase III: Nucleotide Sequence and Expression Studies," Biochemical Genetics, 27 (1/2): 17-30 (1989).
Uemura et al., "Internal Image Anti-Idiotype Antibodies Related to Renal-Cell Carcinoma-Associated Antigen G250," Int. J. Cancer, 56: 609-614 (1994).
Uemura et al., "Vaccination with Anti-Idiotype Antibodies Mimicking a Renal Cell Carcinoma-Associated Antigen Induces Tumor Immunity," Int. J. Cancer, 58: 55-561 (1994).
Uemura et al., "Immunization with Anti-Idiotype Monoclonal Antibodies Bearing the Internal Image of the Renal-Cell Car

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