MMP-12 inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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Details

C560S100000, C562S400000, C562S427000, C514S510000, C514S557000

Reexamination Certificate

active

06897237

ABSTRACT:
A compound of the formula (I):wherein R1is hydroxy and the like; R2is optionally substituted lower alkyl and the like; R3is hydrogen atom and the like; R4is optionally substituted arylene and the like; R5is —C≡C— and the like; R6is optionally substituted naphtyl and the likeits optically active substance, its prodrug, their pharmaceutically acceptable salt, or solvate thereof.

REFERENCES:
patent: 658559 (1995-06-01), None
patent: 757037 (1997-02-01), None
patent: 0 915 086 (1999-05-01), None
patent: 57-59969 (1982-04-01), None
patent: 61-236773 (1986-10-01), None
patent: 63-113455 (1988-05-01), None
patent: 10-204059 (1998-08-01), None
patent: 11-35557 (1999-02-01), None
patent: WO 97 27174 (1997-07-01), None
patent: WO 9745402 (1997-12-01), None
patent: WO 9832748 (1998-07-01), None
patent: WO 9912916 (1999-03-01), None
patent: WO 99 04780 (1999-04-01), None
patent: WO 9942443 (1999-08-01), None
patent: WO 0071506 (2000-05-01), None
patent: WO 0051975 (2000-09-01), None
patent: WO 0051993 (2000-09-01), None
patent: WO 0063194 (2000-10-01), None
Hautamaki et al., “Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice,” Science, 1997, pp. 2002-2004, vol. 277.
Metz et al., “Inhibitors of human neutrophil elastase as a potential treatment for inflammatory diseases,” Exp. Opin. Ther. Patents, 1999, pp. 851-895, vol. 9, No. 7, Ashley Publications Ltd.
Ho et al., “Gene expression, purification and characterization of recombinant human neutrophil collagenase,” Gene, 1994, pp. 297-301, vol. 146; Elsevier Science.
Okada et al., “Matrix Metalloproteinase 9 (92-kDa Gelatinase/Type IV Collagenase) from HT 1080 Human Fibrosarcoma Cells,” Journal of Biological Chemistry, 1992, pp. 21712-21719, vol. 267, No. 30; The American Society for Biochemistry and Molecular Biology, Inc.
Okada et al., “Matrix metalloproteinase 2 from human rheumatoid synovial fibroblasts,” Eur. J. Biochem., 1990, pp. 721-730, vol. 194.
Ward et al., “The purification of tissue inhibitor of metalloproteinases-2 from its 72kDa progelatinase complex,” Biochem. J., 1991, pp. 179-187, vol. 278.
Knight et al., “A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases,” Federation of European Biochemical Societies, 1992, pp. 263-266, vol. 296, No. 3.
Corrie et al., “Synthesis and evaluation of photolabile sulfonamides as potential reagents for rapid photorelease of neuroactive amines,”J. Chem. Soc.,Perkin Trans. 1. 1996, pp. 1583-1592.

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