Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2006-03-14
2006-03-14
Guzu, David (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S029000
Reexamination Certificate
active
07011947
ABSTRACT:
The present invention relates to the diagnosis of mixed lineage leukemia (MLL), acute lymphoblastic leukemia (ALL), and acute myelogenous leukemia (AML) according to the gene expression profile of a sample from an individual, as well as to methods of therapy and screening that utilize the genes identified herein as targets.
REFERENCES:
patent: 5605805 (1997-02-01), Verwer et al.
patent: 5998136 (1999-12-01), Kamb
patent: 6190857 (2001-02-01), Ralph et al.
Lahm, H. et al. “Comprehensive galectin fingerprinting in a panel of 61 human tumor cell lines by RT-PCR and its implications for diagnostic and therapeutic procedures”, May 1991, J. Cancer Res. Clin. Oncol., vol. 127: p. 375-386.
Chang, YY et al., “The effect of galectin-1 on 3T3 cell proliferation on chitosan membranes”, 2004, Biomaterials, vol. 25: p. 3603-3611.
Armstrong, S.A., et al., “The MLL Dependent Gene Expression Profile: Characterization of a Unique Leukemia and Identification of a Potential Molecular Therapeutic Target,”Blood, 98 (11 Part 1):800a (2000).
Chi, Hyun-Sook, et al., “Internal Tandem Duplication of the FLT3 Gene in Acute Leukemia: Clinical and Prognostic Implications in Acute Myeloid Leukemia,”Blood, 96 (11 Part 1):104a (2000).
Imamura, T., et al., “Detection of MLL-AF5q31 Fusion Transcript in an Infantile Acute Lymphoblastic Leukemia Cell Line,”Blood, 98 (11 Part 2):168b (2001).
Kawagoe, H., et al., “Targeted Down-Regulation of MLL-AF9 with Antisense Oligodeoxyribonucleotide Alters the Expression of HOX Genes and Induces Apoptosis in a Human Leukemia Cell LIne THP-1,”Blood, 96 (11 Part 1): 303a(2000).
Shimada, H., et al., “Analysis of Genes Under the Downstream Control of the t(8;21) Fusion Protein AML1-MTG8: Overexpression of the TIS11b (EFR-I, cMG1) Gene Induces Myeloid Cell Proliferation in Response to G-CSF,”Blood, 96:655-663 (2000).
Yuge, M., et al., “Comparison of MRNA Expression Patterns at Diagnosis and Relapse in Acute Lymphoblastic Leukemia by Differential Display Analysis,”Blood, 96 (11 Part 2): 169b (2000).
Armstrong, S. A., et al., “MLL Translocations Specify a Distinct Gene Expression Profile that Distinguishes a Unique Leukemia,”Nature Genetics, 30:41-47 (2002).
Armstrong, S. A., et al., “The Gene Expression Profile of Infant Acute Lymphoblastic Leukemia,”Leukemia, 15 (2001). (Abstract No. 029).
Bavikatty, N.R., et al., “Anti-CD10 Immunoperoxidase Staining of Parrafin-Embedded Acute Leukemias: Comparison With Flow Cytometric Immunophenotyping,”Human Pathology, 31:1051-1054 (2000).
Dong, W-F., et al., “Expression of Rhombotin 2 in Normal and Leukaemic Haemopoietic Cells,”British Journal of Haematology, 93:280-286 (1996).
Dorsam, S., et al., “A Global Survey of Transcriptional Targets of the AML-Associated Homeobox Protein, HOXA9, Using cDNA Microarray Analysis,”Blood, 98(11 Part 1):285A (2001). (Abstract No. 1203).
Ferrando, A. A., et al., “Prognostic Classification of Pediatric T-ALL Using Oligonucleotide Microarrays,”Blood, 98(11 Part 1) :759A-760A (2001). (Abstract No. 3163).
Frank, K. M., et al., “Late Embryonic Lethality and ImpairedV(D)JRecombination in Mice Lacking DNA ligase IV,”Nature, 396:173-177 (1998).
Fruman, D. A., et al., “Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α,”Science, 283:393-397 (1999).
Golub, T.R., et al., “Molecular Classification of Cancer: Class Discovery and Class Prediction by Gene Expression Monitoring,”Science, 286:531-537 (1999).
Hardy, R. R., and Hayakawa, K., “B Cell Development Pathways,”Annual Review of Immunology, 19:595-621 (2001).
Hattenhorst, U., et al., “Differential Gene Expression Analysis in Pediatric Common Acute Lymphoblastic Leukemia Versus Normal Pre-B-Cells and Bone Marrow Utilizing DNA-Microarrays,”Blood, 96(11)(2000). (Abstract No. 458).
Hess, J. L., et al., “The Mixed-Lineage Leukemia Gene (MLL) is Required for Maintenance of HOX Gene Expression and for Normal Hematopoieses,”Blood, 88(10) Supplement 1 (1996). (Abstract No. 179).
Ho, E. L., et al., “MurineNkg2dandCd94are Clustered Within the Natural Killer Complex and are Expressed Independently in Natural Killer Cells,”Proc. Natl. Acad. Sci. USA, 95:6320-6325 (1998).
Kawagoe, L., et al., “Expression of HOXA9, A10 and MLL in Phenotypically and Functionally Defined Subpopulations of Leukemic and Normal Human Hematopoietic Cells,”Blood, 90(10) Supplement 1 (1997) (Abstract No. 1447).
Kern, W., et al., “Correlation of Gene Expression and Protein Expression in Acute Myeloid Leukemia as Assessed by Microarray Analysis and Flow Cytometry,”Blood98(11):1-3 (2001) (Abstract No. 383).
Kondo, M., et al., “Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow,”Cell, 91:661-672 (1997).
LeBien, T.W., “Fates of Human B-cell Precursors,”Blood, 96(1) :9-23 (2000).
Mills, K. I., et al., “Gene Array Chips for Defining Prognosis in Acute Myeloid Leukaemia: A Feasibility Study,”Blood, 98(11 Part 1) (2001) (Abstract No. 379).
Murre, C., “Role of Helix-Loop-Helix Proteins in Lymphocyte Development.” InCold Spring Harbor Symposia on Quantitative Biology, vol. LXIV. (NY: Cold Spring Harbor Laboratory Press), pp. 39-44 (1999).
Nakamura T., et al., “Cooperative Activation ofHoxaandPbx1-Related Genes in Murine Myeloid Leukemias,”Nature Genetics, 12:149-153 (1996).
O'Neill, C. M., et al., “Differential Expression of Homeobox Genes in the Leukaemic Cell Line HL-60 Using Real Time Quantitative PCR,”British Journal of Haematology, 113(Supplement 1):27 (2001). (Abstract No. 100).
Remold-O'Donnell, E., et al., “Sequence and Molecular Characterization of Human Monocyte/Neutrophil Elastase Inhibitor,”Proc. Natl. Acad. Sci. USA, 89:5635-5639 (1992).
Rosenberg, H. F., et al., “Human Eosinophil Cationic Protein: Molecular Cloning of a Cytotoxin and Helminthotoxin with Ribonuclease Activity,”The Journal of Experimental Medicine, 170:163-176 (1989).
Rosnet, O., et al., “HumanFLT3/FLK2Gene: cDNA Cloning and Expression in Hematopoietic Cells,”Blood, 82:1110-1119 (1993).
Rozovskaia, T., et al., “Upregulation ofMeislandHoxA9in Acute Lymphocytic Leukemias with the t(4:11) Abnormality,”Oncogene, 20:874-878 (2001).
Schubart, K., et al., “B Cell Development and Immunoglobuline Gene Transcription in the Absence of Oct-2 and OBF-1,”Nature Immunology, 2(1):69-74 (2001).
Thompson, A., et al., “Small Array Real Time (SMART) Quantitative PCR Profiling of Hox Genes in AML and All Patients,”British Journal of Haematology, 113 (Supplement 1) (2001). (Abstract No. 103).
Thompson, A., et al., “Smart Quantitative PCR Profiling of Hox Gene Expression: Application to Pathogenesis and Treatment Monitoring of Leukemia,”Blood, 96(11)(2000). (Abstract No. 1342).
Yang, R., et al., “Cyclin A1 Expression in Leukemia and Normal Hematopoietic Cells,”Blood, 93:2067-2074 (1999).
Yeoh, E.-J., et al., “Expression Profiling of Pediatric Acute Lymphoblastic Leukemia (ALL) Blasts at Diagnosis Accurately Predicts Both the Risk of Relapse and of Developing Therapy-Induced Acute Myeloid Leukemia (AML),”Blood98 (11 Part 1):(2001) (Abstract No. 1816).
Yin, A. H., et al., “AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells,”Blood, 90:5002-5012 (1997).
Yu, B. D., et al., “AlteredHoxExpression and Segmental Identity inMII-Mutant Mice,”Nature, 378:505-508 (1995).
Armstrong Scott A.
Golub Todd R.
Korsmeyer Stanley J.
Burkhart Michael D.
Dana-Farber Cancer Institute Inc.
Fish & Neave IP Group Ropes & Gray LLP
Guzu David
Whitehead Institute for Biomedical Research
LandOfFree
MLL translocations specify a distinct gene expression... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with MLL translocations specify a distinct gene expression..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and MLL translocations specify a distinct gene expression... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3545100