Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2006-11-14
2006-11-14
Richter, Johann (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S423000, C424S428000, C424S433000, C424S434000, C424S436000, C424S484000, C424S486000, C604S891100
Reexamination Certificate
active
07135190
ABSTRACT:
A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic/hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.
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Piao Ai-Zhi
Shih Chung
Gollamudi Sharmila
Macromed, Inc.
Richter Johann
Thorpe North & Western
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