Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2006-03-28
2006-03-28
Hartley, Michael G. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S428000, C424S430000, C424S434000, C424S443000, C424S449000, C424S451000, C424S457000, C424S468000, C424S484000, C424S486000, C424S464000, C604S891100
Reexamination Certificate
active
07018645
ABSTRACT:
A water soluble, biodegradable reverse thermal gelation system comprising a mixture of at least two types of tri-block copolymer components is disclosed. The tri-block copolymer components are made of a hydrophobic biodegradable polyester A-polymer block and a hydrophilic polyethylene glycol B-polymer block. The drug release and gel matrix erosion rates of the biodegradable reverse thermal gelation system may be modulated by various parameters such as the hydrophobic/hydrophilic component contents, polymer block concentrations, molecular weights and gelation temperatures, and weight ratios of the tri-block copolymer components in the mixture.
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Piao Ai-Zhi
Shih Chung
Gollamudi Sharmila S.
Hartley Michael G.
Macromed, Inc.
Thorpe North & Western LLP
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