Mixtures of particular LMW heparinic polysaccharides for the pro

Details Mixtures of particular LMW heparinic polysaccharides for the pro Mixtures of particular LMW heparinic polysaccharides for the pro

1993-07-16

1995-02-14

Rollins, John W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 54, 536 21, 536 553, A61K 31725, C08B 3710

Patent

active

053896181

ABSTRACT:
Heterogeneous intimate admixtures of sulfated heparinic polysaccharides, well suited for the prophylaxis/treatment of acute thrombotic episodes in a human patient, comprise immixture of sulfated polysaccharides having a weight average molecular weight less than that of heparin and which include from 9% to 20% of polysaccharide chains having a molecular weight less than 2,000 daltons and from 5% to 20% of polysaccharide chains having a molecular weight greater than 8,000 daltons, the ratio between the weight average molecular weight and the number average molecular weight thereof ranging from 1.3 to 1.6.

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Ofosu; Haemostasis 20 (suppl. 1):180-192 (1990).
Hirsh; Adv. Appl. Biotechnol. Ser. 11 (Protein C Relat. Anticoagulants 67-82 (1990).

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