Mixtures of optically active nitrodihydropyridines active on the

Details Mixtures of optically active nitrodihydropyridines active on the Mixtures of optically active nitrodihydropyridines active on the

1985-12-06

1988-08-16

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514332, 514334, 514352, 544333, 546257, 546258, 546263, 546310, 546312, A61K 31455, A61K 31505

Patent

active

047645164

ABSTRACT:
Pure enantiomers of 5-nitrodihydropyridine of the formula ##STR1## are mixed, wherein one of the enantiomers has a high vasodilative action and a low negative inotropic activity on heart muscle, the other enantiomer has a low vasoconstrictive action and a high positive inotropic activity on heart muscle, the mixture being high in vasodilative activity and in positive inotropic activity on heart muscle.

REFERENCES:
patent: 4248873 (1981-02-01), Bossert et al.
patent: 4264611 (1981-04-01), Berntsson et al.
patent: 4492703 (1985-01-01), Goldmann et al.
patent: 4532248 (1985-07-01), Franckowiak et al.
patent: 4678796 (1987-07-01), Taylor et al.
Thomas, G. et al., Journal of Cardiovascular Pharmacy 6 1170-1176 (1984).
Bolger, G. T. et al., Chemical Abstracts 102: 197756e.
Takenaka, T. et al., Japan J. Pharmacol. 32, 665-670 (1982).

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