Mixture of antibiotics produced by a species of actinoplanes

Details Mixture of antibiotics produced by a species of actinoplanes Mixture of antibiotics produced by a species of actinoplanes

1975-08-13

1977-07-26

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

424115, 424120, 424121, A61K 3500

Patent

active

040383830

ABSTRACT:
A species of Actinoplanes, designated Actinoplanes auranticolor ATCC 31011, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of antibiotics which includes a number of macrocyclic lactones and depsipeptides. The individual compounds exhibit significant antibiotic activity. The crude antibiotic mixture or combinations of a pure macrocyclic lactone and a pure depsipeptide demonstrate marked synergistic antibiotic activity. These antibiotics act as growth promotants in chicks and swine and are effective in the treatment of swine dysentery.
This mixture of antibiotics is also produced by a species of Actinoplanes designated Actinoplanes azureus ATCC 31157. In addition, this culture produces a mixture of heptaene antibiotics with antifungal properties.

REFERENCES:
derwent Farm Doc. No. 12766v/07, Abstracting Dutch patent 7,310,613, published 2-4-74.

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