Mixture having antitumor activities

Details Mixture having antitumor activities Mixture having antitumor activities

1995-10-06

1998-01-27

Lankford, Jr., Leon B.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

4242341, 4242481, 435863, 514 23, 514 54, 536123, 5361231, C12P 1900, A61K 3902, A61K 3904, C12N 100

Patent

active

057121230

ABSTRACT:
A purified hot-water extract from Mycobacterium bovis (BCG vaccine) has been found to have significant antitumor activity against a mouse bladder tumor model and a murine sarcoma in vivo, but not in vitro. The material, termed PS1A1, has an approximate molecular weight of between 60 and 90 kDa, is freely soluble in water, but has low solubility in acetone or ethanol, and is remarkably heat-stable.

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Mansell et al. J. Natl. Cancer Inst. (1975) vol. 54, pp. 571-580.
Hunter et al. J. Natl. Cancer Inst. (1978) vol. 60, pp. 419-422.

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