Mixture containing active ingredient and dendritic crystalline s

Details Mixture containing active ingredient and dendritic crystalline s Mixture containing active ingredient and dendritic crystalline s

1980-05-05

1982-09-14

Marantz, Sidney

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Monoclonal antibody or fragment thereof

127 29, 127 31, 127 60, 127 63, 264109, 264122, 434230, 424361, C13K 500, C13K 1100, C13K 1300

Patent

active

043495427

ABSTRACT:
An excipient for tableting of powder mixtures, e.g. pharmaceutical powder mixtures comprises particles of an inert solid material, said particles being of average particle size in the range from 50-1,000 .mu.m in diameter and having surface pores of at least 10 .mu.m in diameter. Preferred excipients comprising dendritic spherulites of sugars e.g. fructose, mannitol or lactose, are prepared by crystallization of sugars under conditions of high crystallization pressure; for instance on addition of crystallizing agents, e.g. ethanol, and/or seeding materials to saturated sugar solutions. The excipients are mixed with finely divided active ingredients e.g. micronized drug particles, and tableted to produce tableted products. The new excipients are suitable for use in direct compression tableting techniques and advantageously diminish problems of excipient/active ingredient segregation during handling of the excipient/active ingredient mixtures.

REFERENCES:
patent: 3169888 (1965-02-01), Ryan
patent: 3337404 (1967-08-01), Polli
patent: 3344030 (1967-09-01), Stevens
patent: 3445283 (1969-05-01), Amano
patent: 3446899 (1969-05-01), Cavalli
patent: 3533805 (1970-10-01), Nava
patent: 3619292 (1971-11-01), Brouillard
patent: 3627583 (1971-12-01), Troy
patent: 3639169 (1972-02-01), Broeg
patent: 3639170 (1972-02-01), Hutton
patent: 3642535 (1972-02-01), Graham
patent: 3721585 (1973-03-01), Francis
patent: 3746554 (1973-07-01), Endicott
patent: 3873694 (1975-03-01), Kanig
patent: 3903255 (1975-09-01), Gusman
patent: 3961004 (1976-06-01), Nasir
patent: 4013775 (1977-03-01), Nelson
patent: 4265847 (1981-05-01), Hunt

Affiliated with

Also associated with

Rating

Mixture containing active ingredient and dendritic crystalline s does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mixture containing active ingredient and dendritic crystalline s, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mixture containing active ingredient and dendritic crystalline s will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2154777