Mixing and separating solid phase supports by pressure variation

Details Mixing and separating solid phase supports by pressure variation Mixing and separating solid phase supports by pressure variation

1986-10-28

1990-10-09

Naff, David M.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

435174, 435177, 435178, 435180, 435803, 435814, 436528, 436531, 436534, 436536, 436538, 436824, 530810, G01N 33543, G01N 33537, G01N 33544, C12N 1100

Patent

active

049620479

ABSTRACT:
Gas containing granules of a resiliently compressible material having a density variable with pressure are used as a solid phase support in liquid phase reactions such in immunological reactions. Varying pressure causes the density of the granules to change and is used for mixing and separating the granules in liquid phase. In an immunological reaction, the granules having an attached antibody are combined with a solution containing an antigen, then varying pressure is applied to the solution to mix the granules in the solution to fix the antigen to the antibody and then pressure on the solution is varied to force the granules to the top or bottom of the solution whereby the solution can be separated from the granules.

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Trevan, M. D., Immobilized Enzymes, John Wiley & Sons, N.Y. 1980, pp. 66-70.
Braun et al., "Cellular and Foamed Plastics as Separation Media", TALANTA, vol. 22, pp. 699-705, Pergamon Press, 1975, Great Britain.

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