Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Structurally-modified antibody – immunoglobulin – or fragment...
Patent
1991-01-24
1998-01-20
Cunningham, Thomas M.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Structurally-modified antibody, immunoglobulin, or fragment...
4241361, 4241781, 435 697, 5303873, 53038822, 530808, 530866, A61K 4500, C07K 1646
Patent
active
057098590
ABSTRACT:
Mixed specificity fusion proteins capable of binding to cellular adhesion molecules have been produced. The fusion proteins contain a polypeptide region, such as an IgG constant region, operatively attached to at least two binding regions each of which corresponds to either an extracellular domain of a cell surface receptor for cellular adhesion molecules, or a variable region of an antibody directed to a cellular adhesion molecule.
A method of inhibiting inflammation is a patient is disclosed in which the present fusion proteins are administered to a patient to inhibit the attachment of inflammatory cells to vascular endothelium.
A method of inhibiting metastasis is disclosed in which the present fusion proteins are administered to a patient to inhibit the metastasis of responsive tumor cells.
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Dietsch, M. T. et al., J. Immunol. Methods 162:123-132, "Bispecific receptor globulins, novel tools for the study of cellular interactions", 1993.
Polte, T. et al., "Full length vascular cell adhesion molecule 1 (VCAM-1)," Nucl. Acids Res. 18(19):5901, 1990.
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Hynes, R.O. Cell 48:549-554, 1987, "Integrins: A Family of Cell Surface Receptors."
Aruffo Alejandro A.
Damle Nitin K.
Fell, Jr. H. Perry
Ledbetter Jeffrey A.
Linsley Peter S.
Bristol--Myers Squibb Company
Cunningham Thomas M.
Sorrentino Joseph M.
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