Mixed micelles

Details Mixed micelles Mixed micelles

1996-03-07

1998-05-05

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

4284022, 514937, 264 41, A61K 9107, A61K 9127

Patent

active

057470669

ABSTRACT:
Mixed micelles for the aqueous solubilization of active substances which are difficultly soluble or insoluble in water with improved storage properties consist of a phosphatide having saturated, branched fatty acid residues and a bile acid salt or dihexanoyllecithin.

REFERENCES:
patent: 4158707 (1979-06-01), Steffen et al.
patent: 4271196 (1981-06-01), Schmidt
patent: 4694084 (1987-09-01), Breuninger et al.
Colloid Polym. Sci., 269(4):412-414 (1991).
English Abstract of EP-A 0388817 (Document B4) Mar. 1990.
English Abstract of EP-A 0471309 (Document B5) Aug. 1981.
Roseman, et al, Properties Of Sonicated Vesicles Of Three Synthetic Phospholipids, Chemistry and Physics of Lipids. vol. 21, pp. 205-222 (1978).
Szoka, et al, Comparative Properties And Methods Of Preparation of Lipid Vesicles (Liposomes).sup.1, Ann. Rev. Biophys. vol. 9, pp. 467-508 (1980).
Menger, et al, Chain-Substituted Lipids In Monolayer Films. A Study of Molecular Packing, J. Am. Chem. Soc. vol. 110, pp. 6797-6803 (1988).
Carey, et al, Micelle Formation by Bile Salts, Arch. Intern. Med. vol. 130, pp. 506-527 (1972).
English Abstract of Document B1 Jan. 1978.
English Abstract for Document B2 Sep. 1988.
English Abstract for Document B3 Jul. 1991.

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