Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Patent
1996-12-27
1999-04-06
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
424400, 424439, 424717, 514 78, 514558, 514937, 514938, A61K 910, A61K 9127
Patent
active
058914668
ABSTRACT:
A composition is disclosed containing nonesterified fatty acids having 14-22 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, monoglycerides which are monoesters of glycerol and fatty acids having 14-22 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid, lysophosphatidylcholine in which the fatty acid moiety has 14-22 carbon atoms of saturated, unsaturated and polyunsaturated fatty acid and bicarbonate. The compositions can optionally also contain bile salts. These compositions form submicron size colloidal particles and can act as vehicles for transporting orally administered drugs, sources of calories in the form of readily absorbable and sustained absorption of fats, sources of readily absorbable polyunsaturated fat and as particles for topical application to the skin. A method of making these particles is also described.
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