Mixed ligand complexes and uses thereof as binding agents to DNA

Details Mixed ligand complexes and uses thereof as binding agents to DNA Mixed ligand complexes and uses thereof as binding agents to DNA

1988-11-07

1992-05-12

Shen, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 10, 546 88, 546275, 556136, 556138, 424 9, 424 11, 424617, 424641, 424646, 424652, 935 77, 935 88, 20415772, C07F 1500, C07D, A61K 3324, A61K 31555

Patent

active

051129744

ABSTRACT:
This invention concerns a coordination complex or salt thereof which is spectroscopically or photoactively determinable when bound to DNA having the formula ##STR1## wherein M is a suitable transition metal and each of R.sub.1, R.sub.2 and R.sub.3 is ethylenediamine, bipyridine, phenanthroline, diazafluorene-9-one or phenanthrenequinonediimine. In the complex, R.sub.1, R.sub.2 and R.sub.3 are bound to M by coordination bonds and R.sub.1 and R.sub.2 may be the same or different and both are different from R.sub.3. In the preferred embodiments, the invention concerns complexes of ruthenium(Ru) or rhodium(Rh) wherein R.sub.1 and R.sub.2 are the same. The invention also concerns the complex ##STR2## wherein M is Ru or Rh and R is 9-10-phenanthrenequinonediimine or 5-nitrophenanthroline.

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