Mixed immunoglobulins for detection of rheumatoid factors

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

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435 71, 435 793, 435 794, 435 795, 436501, 436503, 436506, 436572, 436509, 436513, 436518, 436536, C12Q 100, G01N 3353, G01N 33566

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052524612

ABSTRACT:
Assays are provided for detecting the existence of active rheumatoid arthritis by detecting rheumatoid factor as a blood component which cross-links human IgG with sheep IgG. Particularly, an enzyme labelled assay is provided using biotin-avidin to link the enzyme to the immunoglobulin. The binding peptide of the rheumatoid factor is also provided.

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Clark (1980) "The Experimental Foundations of Modern Immunology" John Wiley & Sons, N.Y. pp. 28-47.
M. Wilchek, et al., Immunology Today, vol. 5, No. 2, pp. 39-43 (1984).
J. T. Barrett, Textbook of Immunology, 3d Ed., C. V. Mosby Company, St. Louis, Mo., pp. 428-430 (1978).

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