Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Reduced antigenicity – reduced ability to bind complement – or...
Patent
1980-05-02
1981-08-18
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Reduced antigenicity, reduced ability to bind complement, or...
2601125R, 26032625, 26032635, 26032636, 26032642, 424274, A61K 3140, C07D207416
Patent
active
042846242
ABSTRACT:
This invention is directed to compounds of the formula ##STR1## wherein A and A.sub.1 are amino acid residues, X is and .alpha.-imino acid residue, and R.sub.1 is hydrogen, lower alkyl, or halo substituted lower alkyl. These compounds are useful as hypotensive agents.
REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4154736 (1979-05-01), Ondetti
patent: 4154935 (1979-05-01), Ondetti et al.
patent: 4154942 (1979-05-01), Ondetti et al.
patent: 4154960 (1979-05-01), Ondetti et al.
patent: 4192878 (1980-03-01), Ondetti
Wong et al., Abstract of Article Appearing in Pharmacologist, vol. 21, p. 173 (1979), The In Vitro Metabolism of C.sup.14 -Captopril in the Blood of Rats, Dogs and Humans.
Lan Shih-jung
Natarajan Sesha I.
Ondetti Miguel A.
Wong Keith K.
Daus Donald G.
Davis Stephen B.
E. R. Squibb & Sons Inc.
Eakin M. C.
Levinson Lawrence S.
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