Mixed crystals of insulin and insulin derivatives

Details Mixed crystals of insulin and insulin derivatives Mixed crystals of insulin and insulin derivatives

1988-05-20

1991-07-02

Moezie, F. T.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 4, 530303, A61K 3726, C07K 740

Patent

active

050285874

ABSTRACT:
Mixed crystals composed of (a) unmodified insulin, des-Phe-B1 insulin, des-Thr-B30 (human) or des-Ala-B30 (pork, beef) insulin and (b) least one insulin having a basic modification at the C-terminal end of the B chain, preferably composed of human insulin and Arg-B31 human insulin and/or Arg.sub.2 -(B31-32) human insulin. These mixed crystals are obtained by crystallization from aqueous solution within a narrow pH range (from about 5.5 to about 6.9). The mixed crystals show a specific moderately prolonged profile and are suitable for the treatment of diabetes mellitus.

REFERENCES:
patent: 2538018 (1951-01-01), Krayenbohl
patent: 4608364 (1986-08-01), Grau
patent: 4701440 (1987-10-01), Grau
Doerschung, Chemical Abstracts, III, 427 (1989), abst. no. 160217q.
U.S. Ser. No. 06/650,639, Obermeier et al., filed Sep. 14, 1984.

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