Mixed complexes as shift and contrast reagents in NMR imaging an

Details Mixed complexes as shift and contrast reagents in NMR imaging an Mixed complexes as shift and contrast reagents in NMR imaging an

1986-06-26

1990-04-10

Warden, Robert J.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

436173, 436806, 128653, 128654, A61K 4900, A61B 600

Patent

active

049159330

ABSTRACT:
Mixed anionic complexes of the type (MW.sub.m Y.sub.n Z.sub.p).sup.r- wherein M is a paramagnetic ion; W, Y, and Z are each different ligands which chelate M; and m+n+p.gtoreq.2 but preferably less than 5, with the proviso that at least two different ligands W, Y, Z are present in the complex; are provided as versatile NMR contrast and shift reagents, especially for clinical diagnostic imaging and spectroscopic procedures. In an exemplary embodiment, at least one of the ligands W, Y, Z is metabolizable by the target tissue, and at least one of the ligands W, Y, Z is substantially inert; the complex is thus tailorable to improve both physiological tolerance and tissue specificity of NMR contrast and shift reagents, while maintaining excellent contrast and shift effects for reliable and accurate results.

REFERENCES:
patent: 3787464 (1974-01-01), Neri et al.
patent: 3789060 (1974-01-01), Goering et al.
patent: 3804868 (1974-04-01), Chabardes et al.
patent: 3915641 (1975-10-01), Goering et al.
patent: 4181672 (1980-01-01), Popper et al.
patent: 4206132 (1980-06-01), Sievers
patent: 4419339 (1983-12-01), Neirinckx
patent: 4481184 (1984-11-01), Kronauge et al.
patent: 4647447 (1987-05-01), Gries et al.
Magnetic Resonance Imaging, vol. 2, pp. 107-112, 1984, "Relaxation Enhancement Using Liposomes Carrying Paramagnetic Species", Caride et al.

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