Mitotic kinesin inhibitors

Details Mitotic kinesin inhibitors Mitotic kinesin inhibitors

2004-08-11

2009-12-29

Saeed, Kamal (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S423000, C514S428000, C514S429000, C546S290000, C546S290000, C546S290000

Reexamination Certificate

active

07638549

ABSTRACT:
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

REFERENCES:
patent: 3644414 (1972-02-01), Helsey et al.
patent: 6057342 (2000-05-01), Fevig et al.
patent: 6440686 (2002-08-01), Sakowicz
patent: 7235580 (2007-06-01), Breslin et al.
patent: 0 418 845 (1995-08-01), None
patent: WO 93/20099 (1993-10-01), None
patent: WO 98/06694 (1998-02-01), None
patent: WO 03/049527 (2003-06-01), None
patent: WO 03/105855 (2003-12-01), None
patent: WO 03/106417 (2003-12-01), None
patent: WO 2004/037171 (2004-05-01), None
patent: WO 2005/019205 (2005-03-01), None
patent: WO 2005/019206 (2005-03-01), None
Patani et al. Chem. Rev., 1996, 96, 3147-49.
C. Sonesson, et al., J. Org. Chem. 1996, vol. 61, pp. 4756-4763.
N. Iwasawa, et al., J. Org. Chem. 1998, vol. 63, pp. 3164-3165.
N. Iwasawa, et al., J. Org. Chem. 1997, vol. 62, pp. 1918-1919.
R. Mison, et al., J. Chem. Research(S), 1989, 126-127.
O. Yebdri, et al., Bulletin De La Societe Chimique de France, 1983, pp. 195-201.
A. Ranjon, Bulletin De La Societe Chimique de France, 1971, pp. 2068-2072.
M. Bujard, et al., Tetrahedron Letters, vol. 40, 1999, pp. 8785-8788.
M. Carpes, et al., Synlett, No. 7, 2000, pp. 1037-1039.
A. Boukhari, et al., J. Cryst. Spect. Res., vol. 19, Iss. 3, 1989, pp. 603-621.
C. Cox, et al., Bioorganic & Medicinal Chem Ltrs. vol. 15, pp. 2041-2045 (2005).
W. Tao, Cell Cycle, vol. 4(11), pp. 1495-1499 (2005).
K. D. Chu, et al., Proc. Am. Soc. Clin. Oncol., abstract 525, pp. 131 (2003).
R. Sakowicz, et al., Cancer Research, vol. 64, pp. 3276-3280 (2004).
W. Tao, et al., Cancer Cell, vol. 8, pp. 49-59 (2005).
M. Fraley, et al., Bioorganic & Medicinal Chem Ltrs., vol. 16, pp. 1775-1779 (2006).
R. Garbaccio, et al., Bioorganic & Medicinal Chem Ltrs., vol. 16, pp. 1780-1783 (2006).
C. Cox, et al., Bioorganic & Medicinal Chem Ltrs., vol. 16, 3175-3179 (2006).
Cox, CD et al., J. Med Chem., vol. XX, pp. XX-XX, (2008), “Kinesin spindle protein (KSP) inhibitors. Part 9: The discovery of KSP inhibitor MK-0731 for the treatment of taxane-refractory cancer”.

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