Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2004-06-08
2008-09-23
Tucker, Zachary C (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S221000
Reexamination Certificate
active
07427637
ABSTRACT:
The present invention relates to bicyclic dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
REFERENCES:
patent: WO 03/105855 (2003-12-01), None
Yildiz and Selvin, “Kinesin: walking, crawling or sliding along?” Trends in Cell Biology, vol. 15(2), pp. 112-120 (Feb. 2005).
Abbas, et al., Bulletin de la Societe Chimique de France, vol. 2, pp. 288-296 (1986).
Chakraborti, et al., Bioorganic & Medicinal Chemistry, vol. 11, pp. 3989-3996 (2003).
Dannhardt, et al., Archic der Pharmazie, vol. 318, pp. 661-663 (1985).
Coleman Paul J.
Neilson Lou Anne
Beeler Nicole M.
Merck & Co. , Inc.
Muthard David A.
Tucker Zachary C
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