Mitotic Kinesin Inhibitors

Details Mitotic Kinesin Inhibitors Mitotic Kinesin Inhibitors

2004-08-11

2010-02-23

Coleman, Brenda L (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C540S602000

Reexamination Certificate

active

07666862

ABSTRACT:
The present invention relates to dihydropyrrole compounds that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention is also related to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.

REFERENCES:
patent: 3644414 (1972-02-01), Helsey, et al.
patent: 6057342 (2000-05-01), Fevig et al.
patent: 6440686 (2002-08-01), Sakowicz
patent: 0 418 845 (1995-08-01), None
patent: WO 93/20099 (1993-10-01), None
patent: WO 98/06694 (1998-02-01), None
patent: WO 03/049527 (2003-06-01), None
patent: WO 03/105855 (2003-12-01), None
patent: WO 03/106417 (2003-12-01), None
patent: WO 2004/037171 (2004-05-01), None
patent: WO 2005/019205 (2005-03-01), None
patent: WO 2005/019206 (2005-03-01), None
C. Sonesson, et al., J. Org. Chem. 1996, vol. 61, p. 4756-4763.
N. Iwasawa, et al., J. Org. Chem. 1998, vol. 63, p. 3164-3165.
N. Iwasawa, et al., J. Org. Chem. 1997, vol. 62, p. 1918-1919.
R. Mison, et al., J. Chem. Research(S), 1989, 126-127.
O. Yebdri, et al., Bulletin De La Societe Chimique de France, 1983, p. 195-201.
A. Ranjon, Bulletin De La Societe Chimique de France, 1971, p. 2068-2072.
M. Bujard, et al., Tetrahedron Letters, vol. 40, 1999, p. 8785-8788.
M. Carpes, et al., Synlett, No. 7, 2000, p. 1037-1039.
A. Boukhari, et al., J. Cryst. Spect. Res., vol. 19, Iss. 3, 1989, p. 603-621.
C. Cox, et al., Bioorganic & Medicinal Chem Ltrs. vol. 15, pp. 2041-2045 (2005).
W. Tao, Cell Cycle, vol. 4(11), pp. 1495-1499 (2005).
K. D. Chu, et al., Proc. Am. Soc. Clin. Oncol., abstract 525, p. 131 (2003).
R. Sakowicz, et al., Cancer Research, vol. 64, pp. 3276-3280 (2004).
W. Tao, et al., Cancer Cell, vol. 8, pp. 49-59 (2005).
M. Fraley, et al., Bioorganic & Medicinal Chem Ltrs., vol. 16, pp. 1775-1779 (2006).
R. Garbaccio, et al., bioorganic & Medicinal Chem Ltrs., vol. 16, pp. 1780-1783 (2006).
C. Cox, et al., bioorganic & Medicinal Chem Ltrs., vol. 16, pp. 3175-3179 (2006).

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