Mitotic inhibitors preventing posterior lens capsule opacificati

Details Mitotic inhibitors preventing posterior lens capsule opacificati Mitotic inhibitors preventing posterior lens capsule opacificati

1983-07-20

1985-05-07

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514912, A61K 31505

Patent

active

045157944

ABSTRACT:
Disclosed are mitotic inhibitors effective for and methods of preventing posterior lens capsule opacification after extracapsular extraction. The mitotic inhibitors comprise osmotically balanced solutions containing either methotrexate or retinoic acid, or both, in at least the minimal effective dosage at the end of one lens epithelial cell cycle. The mitotic inhibitors are instilled in the anterior chamber of the eye preferably immediately after the lens has been removed.

REFERENCES:
patent: 2575168 (1951-11-01), Franklin
patent: 3264295 (1966-08-01), Osdene
patent: 3290312 (1966-12-01), Tschesche et al.
Chem. Abst. 82, 164,719(k) (1975)-McBurney et al.
Chem. Abst. 83, 583(f) (1975)-Bisantis et al.
Chem. Abst. 86, 133,527(z) (1977)-Cohen et al.

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