Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-06-29
1989-10-17
Rizzo, Nicholas S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548415, 548422, 514421, C07D48714, A61K 3140
Patent
active
048747793
ABSTRACT:
Disclosed herein are N.sup.7 -alkylphosphate derivatives of mitomycin C and porfiromycin showing antitumor activity against transplanted human tumor and reduced toxicity relative to the parent N.sup.7 -alkanol mitomycin compounds.
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Iyengar et al, J. Med. Chem., 1981, 24:975-981 and J. Med. Chem., 1983, 26:16-20.
Sinkula & Yalkowsky, J. Pharm. Sci., 1975, 64:181-210 at 189-191. Japan Kokai 21-95, 394 and 21-95, 393, Derwent Abst. No. 87-281016 and 87-281015.
Bristol-Myers Company
Rizzo Nicholas S.
Yang Mollie M.
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