Mitomycin oligonucleotide conjugates

Details Mitomycin oligonucleotide conjugates Mitomycin oligonucleotide conjugates

1996-05-20

1998-07-07

Rories, Charles C. P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

435 6, 435375, 536 245, 548422, A61K 4800, A61K 3174, C07H 2100, C07D48714

Patent

active

057769079

ABSTRACT:
The present invention provides conjugates of mitomycin C or derivatives thereof and oligonucleotides. A conjugate of the present invention corresponds to formula I, below: ##STR1## where R is H, CH.sub.3, or C(O)SCH.sub.3, R' is O or NH, m is an integer from 1 to 10 and Ogn is an oligonucleotide. Pharmaceutical compositions and methods of using such conjugates to inhibit gene product expression are also provided.

REFERENCES:
patent: 5593974 (1997-01-01), Rosenberg et al.
E. Uhlmann et al. Chem. Rev. 90(4)243-84 '90.
C. Stein et al. Science 261: 1004-12 93.
B. Tsang et al. Cancer Gene Therapy 1(1) 65-71 '94.
J. Milligan et al J. Med. Chem. 36 (14) 1923-37 '93.
R. Stull et al. Pharm. Res. 12(4) 465-83 '95.
H. Marvenda et al. FASEB J. 9(6) A1423 Apr. 24, 1995.
Y. Rojanasakul Adv. Drug Del. Rev. 18: 115-131 ('96).

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