Mitomycin C derivatives

Details Mitomycin C derivatives Mitomycin C derivatives

1978-08-28

1980-11-04

Lee, Mary C.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424271, A61K 3140, C07D48704

Patent

active

042319366

ABSTRACT:
The present invention provides new derivatives of mitomycin C, represented by the formula: ##STR1## wherein R represents a hydroxy group in which case the composition is designated as 7-N-(p-hydroxyphenyl)-mitomycin C or an amino group in which case it is designated as 7-N-(p-aminophenyl)-mitomycin C. The new compounds are produced by reacting mitomycin A with p-aminophenyl or p-phenylenediamine and exhibit good antitumor and antibacterial activities.

REFERENCES:
patent: 3332944 (1967-07-01), Cosulich et al.
patent: 3514452 (1970-05-01), Matsui et al.
patent: 4021449 (1977-05-01), Fujimoto et al.
Merck Index, 7th Edition, p. 687 (1960).

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