Mitomycin analogs

Details Mitomycin analogs Mitomycin analogs

1993-05-28

1994-12-20

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D48714, A61K 3140

Patent

active

053747399

ABSTRACT:
The present invention provides novel mitomycin analogs containing a cyclic acetal or thioacetal group. These compounds are mitomycin C analogs in which the 7-amino group bears a 5-membered heterocyclic substituent. Mitomycin C is an antitumor agent of established utility, and the 7-N-substituted mitosane analogs thereof have similar utility.

REFERENCES:
patent: 3332944 (1967-07-01), Cosulich et al.
patent: 3420846 (1967-01-01), Matsui et al.
patent: 3450705 (1969-06-01), Matsui et al.
patent: 3514452 (1970-05-01), Matsui et al.
patent: 4231936 (1980-11-01), Nakano et al.
patent: 4268676 (1981-05-01), Remers
patent: 4460599 (1984-07-01), Remers
patent: 4487769 (1984-12-01), Vyas et al.
patent: 4567256 (1986-01-01), Vyas et al.
patent: 4579737 (1986-04-01), Vyas et al.
Chemical Abstracts vol. 116:75778 (1992).
Chemical Abstracts vol. 113:58753 (1990).
Chemical Abstracts vol. 111:214327 (1989).
Chemical Abstracts vol. 106:32718 (1987).
Matsui, et al., Antibiotics, XXI, 189-198 (1968).
Konishita et al., J. Med. Chem., 14 103-109 (1971).
Iyengar et al., J. Med. Chem., 24 975-981 (1981).
Iyengar, Sami, Remers and Bradner, Abstracts of Papers, 183rd Annual Mtg. of the American Chem. Soc., Las Vegas, Nev., Mar. 1982, Abstract No. MEDI 72.
Iyengar et al., J. Med. Chem., 26, 16-20 (1983).
Iyengar et al., J. Med. Chem., 26, 1453-1457 (1983).
Activity of C-7 Substituted Cyclic Acetal Derivatives of Mitomycin C and Porfiromycin Against Hypoxic and Oxygenated EMT6 Carcinoma Cells In Vitro and In Vivo; Rockwell et al; Cancer Communications, vol. 3, No. 6, 1991, pp. 191-198.

Affiliated with

Also associated with

Rating

Mitomycin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mitomycin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mitomycin analogs will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2386870