Mitogenic peptides

Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – 11 to 14 amino acid residues in defined sequence

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A61K 3702

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active

047044519

ABSTRACT:
Novel tetradecapeptides having the following sequence were found to have potent mitogenic activity for machropage-like cells:

REFERENCES:
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patent: 4517338 (1985-05-01), Urdea et al.
Bar-Shavit et al., "Identification of a Thrombin Sequence with Growth Factor Activity on Macrophages", Proc. Natl. Acad. Sci. USA, vol. 83, pp. 976-980, Feb. 1986.
Perdue, J. Biol. Chem. 256, 2767-2776 (1981).
Bar-Shavit et al., J. Cell Biol. 96, 282-285 (1983).
Bar-Shavit et al., Science 220, 728-730 (1983).
Bar-Shavit et al., J. Cell Biol. 97, 396a, Abstract 1494 (1983).
Butkowski, et al., J. Biol. Chem. 252, 4942-4957 (1977).
Bar-Shavit et al., Biochemistry 23(3) 397-400 (1984).

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